Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Vasodilatory Effect of Nitroglycerin in Cardioplegia Solution on Patients Undergoing Coronary Artery Bypass Graft Surgery Publisher



Hosseini A1 ; Shahzamani M1 ; Amiri F2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Surgery, Chamran Cardiovascular and Medical Research Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2023


Abstract

INTRODUCTION: This study aimed to evaluate the vasodilatory effect of nitroglycerin (NTG) in cardioplegia solution on changes in troponin I and creatine phosphokinase-MB (CPK-MB) levels during coronary artery bypass graft (CABG) surgery. METHOD: A randomized controlled double-blind clinical trial was performed on 44 patients who were candidates for CABG surgery. These patients were divided into two groups. In the first group (NTG group), 3 mg/kg NTG was added to the cardioplegia solution, while 10 cc placebo (distilled water) was added to the cardioplegia solution in the second group (control group). Troponin I and CPK-MB levels were then assessed before and after the surgery. RESULTS: In this study, 72.7% and 27.3% of patients in the NTG group and 68.2% and 31.8% of patients in the control group were male and female, respectively. In addition, 9.1% within the age range of 40-50 years, 27.3% within the age range of 50-60 years, and 63.6% within the age range of more than 60 years were present in the NTG group. Moreover, 18.2% within the age range of 40-50 years, 36.4% within the age range of 50-60 years, and 45.5% within the age range of more than 60 years were present in the control group. Although the mean cardiopulmonary bypass (CPB) and cross-clamp time was insignificantly higher in the NTG group compared to the control group. In addition, troponin I and CPK-MB levels after surgery in the NTG group with the mean of 2090.68 ± 1856.07 and 97.27 ± 38.17 were significantly lower than those of the control group with the mean of 2697.02 ± 5586.56 and 137.95 ± 227.99, respectively (P-value <0.05). CONCLUSION: According to the results of this study, although troponin I and CPK-MB levels increased significantly after CABG surgery, this increase was significantly lower in the intervention group compared to the control group following the administration of NTG. © 2023, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Comparing the Hemodynamic Effects of Nitroglycerin and Labetalol Infusion for Hypertension and Heart Rate Control Before and During Induction to Cardiopulmonary Arrest in Patients Under Coronary Artery Bypass Graft, Journal of Isfahan Medical School (2016)
2. The Comparison of the Effect of Handmade Del Nido and St. Thomas Cardioplegia Solutions on Quantitative Levels of Troponin I and Creatine Kinase-Myocardial Band (Cpk-Mb) in Repair of Pediatric Ventricular Septal Defect, Journal of Isfahan Medical School (2020)
3. Perioperative Myocardial Infarction Diagnosis After Coronary Artery Bypass Grafting Surgery Using Coupled Electrocardiographic Changes and Cardiac Troponin I, Indian Journal of Thoracic and Cardiovascular Surgery (2019)
4. The Effects of Mean Arterial Pressure During Cardiopulmonary Bypass on Clinical and Paraclinical Parameters During and After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2012)
5. Effect of Different Dosages of Nitroglycerin Infusion on Arterial Blood Gas Tensions in Patients Undergoing On- Pump Coronary Artery Bypass Graft Surgery, Journal of Research in Medical Sciences (2012)
6. Effects of a Cardiac Rehabilitation Program on Systolic Function and Left Ventricular Mass in Patients After Myocardial Infarction and Revascularization, Journal of Research in Medical Sciences (2012)
7. The Prevalence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2013)
8. Does Topical Tranexamic Acid Reduce Postcoronary Artery Bypass Graft Bleeding?, Journal of Research in Medical Sciences (2018)
Experts (# of related papers)
View all Related Experts
Mohsen MirMohammad-Sadeghi (10)
Mehran Shahzamani (8)
Other Related Docs
9. The Value of Epicardial Adipose Tissue Thickness for Outcome Prediction of Patients Undergoing Coronary Artery Bypass Grafting Surgery, Journal of Research in Medical Sciences (2019)
10. The Combined Effect of Vitamin C and Omega-3 Polyunsaturated Fatty Acids on Fatigue Following Coronary Artery Bypass Graft Surgery: A Triple-Blind Clinical Trial, Journal of Complementary and Integrative Medicine (2019)
11. Comparison of Blood Electrolytes and Glucose During Cardiopulmonary Bypass in Diabetic and Non-Diabetic Patients, Journal of Research in Medical Sciences (2013)
12. Comparison of the Effect of 1:1 and 1:2 Frequencies of Intra-Aortic Balloon Pump on Hemodynamics of the Patients Undergoing Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2022)
13. A Comparison of the Clinical Outcomes of Minimum and Maximum Hematocrit Levels During Cardiopulmonary Bypass (Cpb) in Low‑Risk Patients Undergoing Coronary Artery Bypass Graft Surgery (Cabg): A Cross‑Sectional Study, Advanced Biomedical Research (2024)
14. Incidence of Atrioventricular Block After Isolated Coronary Artery Bypass Grafting: A Systematic Review and Pooled-Analysis, Frontiers in Cardiovascular Medicine (2023)
15. The Effect of Incentive Spirometry on Arterial Blood Gases After Coronary Artery Bypass Surgery (Cabg), Iranian Journal of Nursing and Midwifery Research (2016)
16. Prognostic Value of Procalcitonin for Morbidity and Mortality in Patients After Cardiac Surgery, Cardiology Research and Practice (2021)
17. Cardiac Fat Pat Change After Laparoscopic Sleeve Gastrectomy and Roux-En-Y Gastric Bypass Surgery: A Systematic Review and Meta-Analysis, Surgery for Obesity and Related Diseases (2023)
18. Is Cardiac Rehabilitation After Pci As Effective As Cabg? the First Experience From the Eastern Mediterranean Region Cardiac Rehabilitation Registry, ARYA Atherosclerosis (2024)
19. The Effect of Zolpidem or Promethazine Premedication on Agitation, Sedation and Cognitive Disorders Before and After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2015)
20. Relationship Between Complete Revascularization and Survival After Post-Infarction Ventricular Septal Rupture, ARYA Atherosclerosis (2023)
21. Efficacy of Epsilon Aminocaproic Acid Versus Placebo in Coronary Artery Bypass Graft: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Treatment Options in Cardiovascular Medicine (2024)
22. Comparison of Survival Rate and Complications of Percutaneous Coronary Intervention, Coronary Artery Bypass Graft, and Medical Treatment in Patients With Left Main And/Or Three Vessel Diseases, ARYA Atherosclerosis (2020)
23. Nifedipine, Captopril or Sublingual Nitroglycerin, Which Can Reduce Blood Pressure the Most?, ARYA Atherosclerosis (2011)
24. Obstructive Sleep Apnea and Postoperative Complications in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Need for Preventive Strategies, International Journal of Preventive Medicine (2014)
25. Differences Between the Characteristics of Ihd Patients Undergoing Different Treatment Modalities Who Adhere to Cardiac Rehabilitation Programs, Iranian Heart Journal (2014)
26. The Effect of N-Acetylcysteine in Prime Solution on Reducing Damage to the Myocardium in Open Heart Surgery, Journal of Isfahan Medical School (2024)
27. Possible Effects of Melatonin on Reperfusion Injury Following Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2022)
28. Comparing the Effects of Hydroxy Ethyl Starch 6% and Gelatin As Replacement for Prime During Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2013)
29. The Association Between Serum Lactate Level and Post Cabg Complications in Cardiac Patients, Journal of Isfahan Medical School (2011)
30. Early Chest Tube Removal After Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2010)
31. Exercise-Based Cardiac Rehabilitation Improves Hemodynamic Responses After Coronary Artery Bypass Graft Surgery, ARYA Atherosclerosis (2012)
32. Evaluating Hemodynamic Outcomes of Different Dosages of Intravenous Nitroglycerin After Coronary Artery Bypass Graft Surgery, Journal of Research in Medical Sciences (2011)
33. Effects of Single Antegrade Hot Shot in Comparison With No Hot Shot Administration During Coronary Artery Bypass Grafting, ARYA Atherosclerosis (2015)
34. Preconditioning by Isoflurane As a Volatile Anesthetic in Elective Coronary Artery Bypass Surgery, ARYA Atherosclerosis (2013)
35. The Effect of Metoprolol During Rewarming on the Incidence of Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting, Journal of Isfahan Medical School (2021)
36. Can Cardiac Rehabilitation Programs Improve Functional Capacity and Left Ventricular Diastolic Function in Patients With Mechanical Reperfusion After St Elevation Myocardial Infarction?: A Double-Blind Clinical Trial, ARYA Atherosclerosis (2012)
37. The Effect of N-Acetylcysteine in Prime Solution on Preventing Renal Failure During Cardiopulmonary Bypass Surgery, Journal of Isfahan Medical School (2021)
38. Comparing the Hemodynamic Changes During and After Coronary Artery Bypass Graft Surgery Under General Anesthesia With Propofol and Isoflurane, Journal of Isfahan Medical School (2015)
39. To Reverse or Not to Reverse the Radial Artery in Coronary Artery Bypass Graft Surgery? Histopathologic Concerns and Media Thickness, Heliyon (2023)
40. The Relation Between the Mean Time Interval of Opening of Aortic Cross Clamp to the End of Cardiopulmonary Bypass With Surgical Results of Patient After Coronary Artery Bypass Grafting Surgery, Journal of Isfahan Medical School (2017)
41. Comparative Study of Clinical Outcomes of Methylprednisolone and Dexamethasone in Prime Solution During Cardiopulmonary Pump After Coronary Artery Bypass Grafting, Journal of Cellular and Molecular Anesthesia (2021)
42. Detrimental Predictive Effect of Metabolic Syndrome on Postoperative Complications in Patients Who Undergoing Coronary Artery Bypass Grafting, Acta Biomedica (2015)
43. Evaluating the Relative Frequency and Predicting Factors of Acute Renal Failure Following Coronary Artery Bypass Grafting, ARYA Atherosclerosis (2013)
44. Predictive Value of P-Wave Duration and Dispersion in Post Coronary Artery Bypass Surgery Atrial Fibrillation, ARYA Atherosclerosis (2012)
45. Effect of Low-Dose Dopamine on Lactate Level in Patients Undergoing Coronary Bypass Surgery, Iranian Heart Journal (2013)
46. The Effect of Intravenous Injection of Amiodarone on Central Venous Pressure in Patients Undergoing Coronary Artery Bypass Graft Surgery, Journal of Isfahan Medical School (2018)
47. Long-Term Effect of Enhanced External Counterpulsation on Endothelial Function in the Patients With Intractable Angina, Heart Lung and Circulation (2008)
48. A Comparative Study of Stored Arterial Versus Venous Blood Collected Using the Acute Normovolemic Hemodilution Method in Coronary Artery Bypass Grafting Patients in Iran, Acute and Critical Care (2023)
49. Incidence of Postoperative Stroke After Coronary Artery Bypass Surgery and Its Risk Factors, Journal of Babol University of Medical Sciences (2011)
50. Evaluation of the Effectiveness of Curcumin and Piperine Co-Supplementation on Inflammatory Factors, Cardiac Biomarkers, Atrial Fibrillation, and Clinical Outcomes After Coronary Artery Bypass Graft Surgery, Clinical Nutrition ESPEN (2024)