Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Acorus Calamus L. in Preventing Memory Loss, Anxiety, and Oxidative Stress on Lipopolysaccharide-Induced Neuroinflammation Rat Models Publisher



Esfandiari E1 ; Ghanadian M2 ; Rashidi B1 ; Mokhtarian A1 ; Vatankhah A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pharmaceutical Sciences Research Center, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Drug Applied Research Center, Tabriz Medical University, Tabriz, Iran

Source: International Journal of Preventive Medicine Published:2018


Abstract

Objective: Several factors lead to memory loss, the most important of which is brain aging that is caused mostly by neuroinflammation and oxidative stress. The need of finding preventive treatments of memory impairment in elderly encouraged authors to assess the effect of Acorus calamus on memory loss, anxiety, and antioxidant indices on neuroinflammation rat models. Materials and Methods: Different fractions of A. calamus were prepared. The subject rats were grouped in 11 groups of 10 each. In the nine treated groups, the extract gavage began 1 week before intraperitoneal (i.p.) injection of lipopolysaccharide (LPS) and continued for 2 weeks after the last injection of LPS. Behavioral tests, including passive avoidance and elevated plus-maze (EPM) tests, were run on days 24, 25, and 26 and the subjects were sacrificed on the day after the last behavioral test, and their hippocampus was isolated to measure the oxidative stress markers. Results: Assessment of oxidative stress markers in hippocampus samples revealed that the amounts of endogenous antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and total antioxidant activity) in the groups that received different fractions were less than their equivalent figures in LPS-control group, and levels of malondialdehyde (MDA) in treatment groups were less than MDA level in LPS-control group. Moreover, the treatment groups with different fractions of A. calamus revealed better performance compared to LPS-control group in shuttle-box test. In EPM test, the groups with different fractions revealed lower stress level in comparison with LPS-control group. The best performance in memory test and the lowest level of stress in EPM was observed in the group with aqueous fraction at 600 mg/kg dose, and the least figures of oxidative stress markers were of the group with aqueous fraction at 600 mg/kg dose. Conclusion: The oral administration of different fractions of A. calamus, especially aqueous fraction, prevented from memory deficits and stress through controlling oxidative stress and inflammation processes. © 2018 International Journal of Preventive Medicine | Published by Wolters Kluwer - Medknow.
Related Docs
View other Related Docs
1. Gallic Acid Ameliorates Lps-Induced Memory Decline by Modulating Nf-Κb, Tnf-Α, and Caspase 3 Gene Expression and Attenuating Oxidative Stress and Neuronal Loss in the Rat Hippocampus, Metabolic Brain Disease (2025)
2. Neuroprotective Effects of Levisticum Officinale on Lps-Induced Spatial Learning and Memory Impairments Through Neurotrophic, Anti-Inflammatory, and Antioxidant Properties, Food and Function (2020)
3. The Effect of Ghrelin on Antioxidant Status in the Rat's Model of Alzheimer's Disease Induced by Amyloid-Beta, BioMedicine (Taiwan) (2022)
4. Neuroprotective Effects of Sesamol Against Lps-Induced Spatial Learning and Memory Deficits Are Mediated Via Anti-Inflammatory and Antioxidant Activities in the Rat Brain, Avicenna Journal of Phytomedicine (2023)
5. Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats, Advanced Biomedical Research (2022)
6. Effects of Crocin on Spatial or Aversive Learning and Memory Impairments Induced by Lipopolysaccharide in Rats, Avicenna Journal of Phytomedicine (2021)
7. Crocin Improves Cognitive Impairment in Lps-Treated Rats Through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities, Molecular Neurobiology (2024)
8. The Protective Effects of Escitalopram on Chronic Restraint Stress-Induced Memory Deficits in Adult Rats, Physiology and Pharmacology (Iran) (2022)
Experts (# of related papers)
View all Related Experts
Hojatallah Alaei (27)
Parham Reisi (21)
Other Related Docs
9. The Effect of Pentoxifylline on Passive Avoidance Learning and Expression of Tumor Necrosis Factor-Alpha and Caspase-3 in the Rat Hippocampus Following Lipopolysaccharide-Induced Inflammation, Advanced Biomedical Research (2019)
10. Effects of Hydroalcoholic, Methanolic, and Hexane Extracts of Brown Algae Sargassum Angustifolium on Scopolamine-Induced Memory Impairment and Learning Deficit in Rodents, Research in Pharmaceutical Sciences (2023)
11. Treadmill Running and Levisticum Officinale Extract Protect Against Lps-Induced Memory Deficits by Modulating Neurogenesis, Neuroinflammation and Oxidative Stress, Metabolic Brain Disease (2023)
12. Effects of Piper Nigrum Fruit and Cinnamum Zeylanicum Bark Alcoholic Extracts, Alone and in Combination, on Scopolamine-Induced Memory Impairment in Mice, Research in Pharmaceutical Sciences (2021)
13. The Effect of Rosemary Extract on Spatial Memory, Learning and Antioxidant Enzymes Activities in the Hippocampus of Middle-Aged Rats, Medical Journal of the Islamic Republic of Iran (2015)
14. Effects of Cyperus Rotundus Extract on Spatial Memory Impairment and Neuronal Differentiation in Rat Model of Alzheimer’S Disease, Advanced Biomedical Research (2020)
15. Myrtenol Ameliorates Recognition Memories' Impairment and Anxiety-Like Behaviors Induced by Asthma by Mitigating Hippocampal Inflammation and Oxidative Stress in Rats, NeuroImmunoModulation (2023)
16. The Effect of Iron and Cholesterol on Neuronal Apoptosis in Dentate Gyrus of Hippocampus in Rabbits Fed With High-Cholesterol Diet, Journal of Isfahan Medical School (2015)
17. G-Csf Improved the Memory and Dendritic Morphology Impairments in the Hippocampal Ca1 Pyramidal Neurons After Brain Ischemia in the Male Rats, Metabolic Brain Disease (2023)
18. Crocin Improves Spatial Learning and Memory Deficits in the Morris Water Maze Via Attenuating Cortical Oxidative Damage in Diabetic Rats, Neuroscience Letters (2017)
19. Can Psychobiotics Administration Influence Behavioral Responses and Physiological Stress in Healthy Rats?, Pharmaceutical Sciences (2022)
20. The Role of Cyclooxygenase 2 in the Cognitive Impairment Induced by Alcohol or Stress in Rats, Advanced Biomedical Research (2021)
21. Neuroprotective Effects of Flavonoids, Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects (2023)
22. The Effect of Agelena Labyrinthica Total Venom and Its Agatoxin Fraction on the Kainic Acid-Induced Cognitive Disorder in Rat, Journal of Isfahan Medical School (2021)
23. The Effect of Treadmill Running on Memory Before and After the Nbm-Lesion in Rats, Journal of Bodywork and Movement Therapies (2013)
24. The Effect of Erythropoietin on Neuronal Apoptosis in Hippocampal Dentate Gyrus in Streptozotocin-Induced Alzheimer’S Disease in Rats, Journal of Isfahan Medical School (2018)
25. The Effect of Treadmill Running on Passive Avoidance Learning in Animal Model of Alzheimer Disease, International Journal of Preventive Medicine (2013)
26. Novel Effects of Rosa Damascena Extract on Memory and Neurogenesis in a Rat Model of Alzheimer's Disease, Journal of Neuroscience Research (2014)
27. Lipopolysaccharide-Induced Memory Impairment in Rats Is Preventable Using 7-Nitroindazole; [O Deficit De Memoria Induzido Por Lipossacarideos Em Ratos E Prevenido Por Nitroindazol], Arquivos de Neuro-Psiquiatria (2015)
28. The Effect of Regular Exercise on Antioxidant Enzyme Activities and Lipid Peroxidation Levels in Both Hippocampi After Occluding One Carotid in Rat, Journal of Physiological Sciences (2014)
29. The Effects of Anethum Graveolens Essence on Scopolamine-Induced Memory Impairment in Mice, Research in Pharmaceutical Sciences (2016)
30. Neuronal Nitric Oxide Synthase Has a Role in the Detrimental Effects of Lipopolysaccharide on Spatial Memory and Synaptic Plasticity in Rats, Pharmacological Reports (2016)
31. Effect of Hydro-Alcoholic Extract of Nigella Sativa on Cisplatin-Induced Memory Impairment and Brain Oxidative Stress Status in Male Rats, Avicenna Journal of Phytomedicine (2024)
32. The Effect of Ghrelin on Apoptosis, Necroptosis and Autophagy Programmed Cell Death Pathways in the Hippocampal Neurons of Amyloid-Β 1–42-Induced Rat Model of Alzheimer’S Disease, International Journal of Peptide Research and Therapeutics (2022)
33. Effects of Amitriptyline and Fluoxetine on Synaptic Plasticity and Tnf-Α Level at Hippocampus of Streptozotocin-Induced Diabetic Rats, Physiology and Pharmacology (2017)
34. A Possible Mechanism for the Anxiolytic-Like Effect of Gallic Acid in the Rat Elevated Plus Maze, Pharmacology Biochemistry and Behavior (2014)
35. Effect of Aging and Regular Exercise on Prefrontal Cortex Histopathology, Myelin Density, and Antioxidant Activity of the Rats, Journal of Advances in Medical and Biomedical Research (2024)
36. Saffron (Crocus Sativus L.) Extract Prevents and Improves D-Galactose and Nano 2 Induced Memory Impairment in Mice, EXCLI Journal (2012)
37. Effects of Folic Acid on Passive Avoidance Learning and Memory in Rat Alzheimer Model by Intracerebroventricular Injection of Streptozotocin, Journal of Isfahan Medical School (2010)
38. Comparing the Therapeutic Effects of Crocin, Escitalopram and Co-Administration of Escitalopram and Crocin on Learning and Memory in Rats With Stress-Induced Depression, Malaysian Journal of Medical Sciences (2021)
39. Comparative Effects of Chronic Administrations of Gabapentin, Pregabalin and Baclofen on Rat Memory Using Object Recognition Test, Research in Pharmaceutical Sciences (2017)
40. Comparing the Effects of Crocin at Different Doses on Excitability and Long-Term Potentiation in the Ca1 Area, As Well As the Electroencephalogram Responses of Rats Under Chronic Stress, Metabolic Brain Disease (2021)
41. Effects of Crocin on Brain Oxidative Damage and Aversive Memory in a 6-Ohda Model of Parkinson’S Disease; [Efeitos Da Crocina No Dano Oxidativo Cerebral E Na Memoria Aversiva Em Um Modelo 6-Ohda De Doenca De Parkinson], Arquivos de Neuro-Psiquiatria (2016)
42. Effects of Extracts and Manna of Echinops Cephalotes on Impaired Cognitive Function Induced by Scopolamine in Mice, Research in Pharmaceutical Sciences (2024)
43. Evaluation of the Effects of Red Grape Juice on Alzheimer's Disease in Rats, Journal of Isfahan Medical School (2012)
44. The Impact of Sesamol and Exercise on Striatal Tnf-Α Level, Motor Behavior, Aversive Memory and Oxidative Stress Status in 6-Hydroxydopamine-Lesioned Rats, Physiology and Pharmacology (Iran) (2022)
45. The Protective Effects of Escitalopram on Synaptic Plasticity in the Ca1 Region of Chronically Stressed and Non-Stressed Male Rats, International Journal of Developmental Neuroscience (2022)
46. Effects of Carvacrol on Spatial Learning Performances, Hippocampal Interleukin-1ß Level and Oxidative Stress Markers in Lipopolysaccharide-Treated Rats, Physiology and Pharmacology (Iran) (2019)
47. The Dose-Dependent Neuroprotective Effect of Norepinephrine in Improving Memory Retrieval in an Experimental Model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Brain Research Bulletin (2024)
48. Effect of Forced Treadmill Exercise on Stimulation of Bdnf Expression, Depression Symptoms, Tactile Memory and Working Memory in Lps-Treated Rats, Behavioural Brain Research (2022)
49. Treadmill Running Improves Spatial Memory in an Animal Model of Alzheimer's Disease, Behavioural Brain Research (2011)
50. The Effects of Doxepin on Stress-Induced Learning, Memory Impairments, and Tnf-A Level in the Rat Hippocampus, Research in Pharmaceutical Sciences (2015)