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A Novel Mutation in Slc3a1 Gene in Patients With Cystinuria Pubmed



Markazi S1 ; Kheirollahi M2 ; Doosti A1 ; Mohammadi M3 ; Koulivand L2
Authors
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Authors Affiliations
  1. 1. Department of Molecular Genetics, Biotechnology Research Center, Islamic Azad University, Shahrekord, Iran
  2. 2. Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Noncommunicable Diseases and Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Depatment of Urology, Urology and kidney Transplantation Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Kidney Diseases Published:2016


Abstract

Cystinuria is an inherited disease characterized by the formation of cystine calculi in the kidneys, ureters, and bladder. Cystinuria is associated with mutation in the SLC3A1 and SLC7A9 genes. These defects prevent appropriate reabsorption of dibasic amino acids lysine, ornithine and arginine. Cystinuria is classified as type I (silent heterozygotes) and non-type I (heterozygotes with urinary hyperexcretion of cystine). In molecular term, cystinuria is classified as type A (mutations on SLC3A1 gene) and type B (mutations on SLC7A9 gene). This report describes 7 patients with early onset of cystine calculus formation. We are report a new mutation in SLC3A1 gene in exon 1. A novel nucleotide substitution c.-29A>G was found in exon 1 of the SLC3A1 gene, which had not been reported elsewhere previously. © 2016, Iranian Society of Nephrology. All Rights Reserved.
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