Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Freezing and Thawing Process on Betamethasone Acetate Release From Polyvinyl Alcohol Nanospheres Publisher



Bonakdar S1 ; Poursamar SA2 ; Rafienia M3 ; Shokrgozar M4 ; Farhadi A5 ; Hosseini M2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Islamic Azad University of Mashhad, Mashhad, 91735-413, Iran
  2. 2. Amirkabir University of Technology, Biomedical Engineering Department, Tehran, 15875-4413, Iran
  3. 3. Isfahan University of Medical Sciences, Physics and Biomedical Engineering Department, Isfahan, 81745, Iran
  4. 4. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  5. 5. Tehran Medical Branch of Islamic Azad University, Amiralmomenin Hospital, Iran

Source: Solid State Phenomena Published:2009


Abstract

Betamethasone acetate (BA) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching. In this research, polyvinyl alcohol nanospheres loaded by betamethasone acetate were prepared by oil in water emulsion method after which they were exposed to 1, 2 and 4 cycles of freeze-thawing (F-T) process including 24 hours freezing cycle at -25 °C and 24 hours thawing at ambient temperature. Nanospheres fabrication was confirmed by transmission electron microscopy and betamethasone release was analyzed by UV spectrophotometer at 245 nm. The results revealed that by increasing the number of F-T cycles the rate of drug release decreased. The effect of BA concentration was also investigated on human chondrosarcoma (sw 1353). The MTT assay was utilized to assess the cell proliferation. The results showed that these biocompatible nanospheres can be used for sustained release of such drugs for more than four months and drug release rate can be effectively controlled by implementing F-T cycles. © (2009) Trans Tech Publications.
Related Docs
1. Investigation of Drug Release From Biodegradable Polymeric Delivery System by Infrared Spectrometry, International Journal of Polymer Analysis and Characterization (2008)
2. Ciprofloxacin Loaded Alginate/Chitosan and Solid Lipid Nanoparticles, Preparation, and Characterization, Journal of Dispersion Science and Technology (2012)
3. Pharmaceutical Evaluation of Atorvastatin-Loaded Nanostructured Lipid Carriers Incorporated Into the Gelatin/Hyaluronic Acid/Polycaprolactone Scaffold for the Skin Tissue Engineering, Journal of Biomaterials Applications (2021)
4. Investigation of Drug Release and 1H-Nmr Analysis of the in Situ Forming Systems Based on Poly(Lactide-Co-Glycolide), Polymers for Advanced Technologies (2009)
5. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
6. Preparation, Optimization, and Screening of the Effect of Processing Variables on Agar Nanospheres Loaded With Bupropion Hcl by a D-Optimal Design, BioMed Research International (2015)
7. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (4)
Mohammad Rafienia (2)