Impact of an 8-Week Home-Based Resistance Training and Leisure-Time Physical Activity on Serum Glucagon-Like Peptide-1 and Microrna-192 Levels in Children With Type 1 Diabetes: A Randomized Clinical Trial Publisher



Nazari M ; Minasian V ; Hovsepian S
Source: Journal of Research in Medical Sciences Published:2025

Abstract

Background: While numerous studies highlight the significant health benefits of physical activity, there is limited research on the effect of various exercise training in children with type 1 diabetes mellitus (T1DM). The current study aimed to investigate the effects of physical activity on the expression of microRNA (miRNA)-192, serum glucagon-like peptide-1 (GLP-1) level, and some factors related to T1DM in children. Materials and Methods: In this randomized clinical trial study, a total of 20 children with T1DM were randomly divided into the following two groups and trained for 8 weeks: home-based resistance training (HBRT) (n = 10, age = 12.6 years) and leisure-time physical activity (n = 10, age = 12.4 years). Metabolic biomarkers, serum levels of miRNA-192, GLP-1, and other relevant measurements were assessed in each patient 48 h before and after completing the 8-week training program. Results: The findings showed that in both the training groups, fasting blood glucose concentrations decreased significantly, and maximum oxygen consumption (VO2 max) increased significantly (P ≤ 0.05). Furthermore, a significant difference was identified between the cardiovascular endurance (VO2 max) levels of the two groups, with the HBRT group demonstrating a more substantial improvement. Although increased levels of fasting insulin and decreased levels of glycated hemoglobin were not significant in both the groups (P ≥ 0.05), a significant increase was observed in the GLP-1 serum levels of both the groups and their miRNA-192 levels decreased by 58%–60% (P ≥ 0.05). Conclusion: Encouraging children with T1DM to do appropriate exercise training workouts at home as well as proper physical activities during their leisure time can be effective in reducing potential complications in patients and improving their health. © 2025 Elsevier B.V., All rights reserved.