Neurological Manifestations of Allgrove Syndrome



Etemadyfar M¹ ; Khodabandehlou R¹
Source: Archives of Iranian Medicine Published:2004

Abstract

Allgrove syndrome is a rare syndrome with conspicuous neurological abnormalities. We describe a 16-year-old male with Allgrove syndrome suffering from upper and lower motor neuron diseases, autonomic dysfunction, muscle weakness, seizure, optic atrophy, ataxia, and peripheral demyelinating polyneuropathy primarily involving distal lower limbs. Since 3 years of age, he had experienced frequent hospital admissions for convulsion, hypoglycemia, dysphagia, intractable vomiting, loss of consciousness, treatment of achalasia, and suspicious seizure. His younger sister had died at the age of 3 with no diagnosis. Early treatments with corticosteroids dramatically improved his signs and symptoms.