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The Efficacy of Repetitive Transcranial Magnetic Stimulation (Rtms) Versus Transcranial Direct‑Current Stimulation (Tdcs) on Migraine Headaches: A Randomized Clinical Trial Publisher



Naji F1 ; Sharbafchi MR1 ; Khorvash F2 ; Maracy MR1, 3 ; Ghasemi Mobarak Abadi N1, 3
Authors
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Authors Affiliations
  1. 1. Department of Psychiatry, School of Medicine, Nour and Ali‑Asghar Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Neurology, School of Medicine, Neurosciences Research Center, Al‑Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Health, Environment Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Advanced Biomedical Research Published:2024


Abstract

Background: Non‑pharmacologic prophylactic methods for chronic migraine have been developed, including the promising non‑invasive techniques of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct‑current stimulation (tDCS). This study aimed to compare the efficacy of rTMS and tDCS on pain intensity, the impact of headaches on daily life, anxiety, and depression in migraine headaches patients. Materials and Methods: This randomized clinical trial was conducted on 72 patients with migraine headaches, randomly allocated to the rTMS and tDCS groups. Participants received 3 and 12 sessions of stimulation over the left dorsolateral prefrontal cortex (DLPFC), respectively. Follow‑up measurements, including pain intensity, anxiety, depression, and impact on daily life, were performed one month after the last sessions. Analyses were done by IBM SPSS statistics version 26 software. Results: Of 72 patients enrolled in the study, 19 were male (8 in the rTMS group and 11 in the tDCS group). There was no significant difference in baseline characteristics between groups. During the follow‑up visit, both groups showed a decrease in anxiety levels (P values = 0.005 and 0.015), while only the rTMS group displayed a significant improvement in depression (P value = 0.01). However, no statistically significant difference was found among the groups regarding changes in pain intensity, anxiety, and the impact of headaches on daily life (P values >0.05). Conclusion: Our findings suggest that both rTMS and tDCS may be effective in reducing pain intensity and improving the impact of headaches on daily life and anxiety in patients with chronic migraine. However, significant improvement in depression was only observed in the rTMS group patients. © 2024 Advanced Biomedical Research Published by Wolters Kluwer - Medknow.
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