Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluating the Role of Biochanin a in Acetic Acid-Induced Colitis in Rats: Involvement of Nitric Oxide Pathway Publisher



Farzaei MH1 ; Tahani A2 ; Morovati MR3 ; Ghanbarimovahed M1 ; Asgary S4 ; Shirooie S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Persian Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Isfahan Cardiovascular Research Centre, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Research Journal of Pharmacognosy Published:2024


Abstract

Background and objectives: Inflammatory bowel disease (IBD) refers to idiopathic chronic and inflammatory bowel disorders such as ulcerative colitis. Considering the lack of definitive treatment and the side effects of existing drugs, finding efficient compounds is needed. Biochanin A has attracted the attention of researchers due to its wide range of medicinal activities. Until now, no study was conducted to evaluate its effects on colitis. Therefore, the aim of this study was to determine the effect of biochanin A on the nitrogen pathway in rats with acetic acid-induced colitis. Methods: Male rats were divided into five groups: normal group, negative control group, positive control group, and groups receiving biochanin A (10 and 20 mg/kg). Colitis was induced with 4% acetic acid. Next, the samples were evaluated at different macroscopic and microscopic levels, and biochemical test of superoxide dismutase (SOD) and nitric oxide activity was investigated. Results: Macroscopic and microscopic investigations showed that treatment with biochanin A decreased mucosal damage in rats with acetic acid-induced colitis. Biochanin A reduced neutrophil infiltration in the intestinal tissue. It also led to the reduction in nitric oxide and enhancement of SOD in rats. The optimal dose of biochanin A was 20 mg/kg, which had the best effect on reducing inflammation and mucosal lesions in rats. Conclusion: Biochanin A, due to its anti-inflammatory effects by reducing nitric oxide and enhancement of SOD and reducing mucosal damage in rats with acetic acid-induced colitis, can be a useful alternative drug for the prevention or treatment of IBD patients. © 2024. Open access.
Related Docs
View other Related Docs
1. Protective Effects of Walnut Extract Against Oxidative Damage in Acetic Acid-Induced Experimental Colitis Rats, Physiology and Pharmacology (Iran) (2019)
2. Antioxidant Effects of Methanol Extract of Dracocephalum Kotschyi in Acetic Acid Induced Rat Colitis Model, Journal of Advances in Medical and Biomedical Research (2022)
3. Effect of Matricaria Aurea (Loefl.) Shultz-Bip. Hydroalcoholic Extract on Acetic Acid-Induced Acute Colitis in Rats, Iranian Journal of Basic Medical Sciences (2011)
4. Anti-Inflammatory Effect of Curcuma Longa on Ulcerative Colitis Caused Via Acoh in Rats, Journal of Medicinal and Chemical Sciences (2023)
5. Colon Delivery of Budesonide Using Solid Dispersion in Dextran for the Treatment and Secondary Prevention of Ulcerative Colitis in Rat, International Journal of Preventive Medicine (2010)
6. Anti-Inflammatory Effect of Myrtus Communis Hydroalcoholic Extract and Essential Oil on Acetic Acid-Induced Colitis in Rats, Journal of Reports in Pharmaceutical Sciences (2019)
7. Anti-Inflammatory Effects of Ketotifen in Acetic Acid-Induced Ulcerative Colitis in Rats, Journal of Isfahan Medical School (2013)
8. Effectiveness of Budesonide-Succinate-Dextran Conjugate As a Novel Prodrug of Budesonide Against Acetic Acid-Induced Colitis in Rats, International Journal of Colorectal Disease (2010)
Experts (# of related papers)
View all Related Experts
Mohsen Minaiyan (41)
Parvin Mahzouni (22)
Other Related Docs
9. Protective Effect of Ocimum Basilicum Essential Oil Against Acetic Acid–Induced Colitis in Rats, Journal of Evidence-Based Complementary and Alternative Medicine (2016)
10. Preventive Therapy of Experimental Colitis With Selected Iron Chelators and Anti-Oxidants, International Journal of Preventive Medicine (2012)
11. Protective Effect of Apium Graveolens L. (Celery) Seeds Extracts and Luteolin on Acetic Acid-Induced Colitis in Rats, International Journal of Preventive Medicine (2021)
12. Protective Effect of Ginger Volatile Oil Against Acetic Acid-Induced Colitis in Rats: A Light Microscopic Evaluation, Journal of integrative medicine (2014)
13. Salvia Officinalis Leaf Extracts Protect Against Acute Colitis in Rats, Research in Pharmaceutical Sciences (2022)
14. Anti-Inflammatory Effect of Apigenin and Hydroalcoholic Extract of Dracocephalum Kotschyi on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2017)
15. Reactive Oxygen Metabolites and Anti-Oxidative Defenses in Aspirin-Induced Gastric Damage in Rats: Gastroprotection by Vitamin E, Pathophysiology (2006)
16. Does Cisapride, As a 5Ht 4 Receptor Agonist, Aggravate the Severity of Tnbs-Induced Colitis in Rat?, Gastroenterology Research and Practice (2012)
17. Preparation of Budesonide-Dextran Conjugates Using Glutarate Spacer As a Colon-Targeted Drug Delivery System: In Vitro/In Vivo Evaluation in Induced Ulcerative Colitis, Journal of Drug Targeting (2011)
18. Effects of Silibin Nanocapsules on Acetic Acid Induced Ulcerative Colitis in Rats, Journal of Isfahan Medical School (2013)
19. Spasmolytic Activity of Essential Oil and Various Extracts of Ferula Gummosa Boiss. on Ileum Contractions, Phytomedicine (2001)
20. Anti-Inflammatory Effect of Prunus Armeniaca L. (Apricot) Extracts Ameliorates Tnbs-Induced Ulcerative Colitis in Rats, Research in Pharmaceutical Sciences (2014)
21. Investigating the Impact of Selected B Vitamins (B1, B2, B6, and B12) on Acute Colitis Induced Experimentally in Rats, International Journal of Preventive Medicine (2024)
22. Preparing Simvastatin Nanoparticles by a Combination of Ph-Sensitive and Timed-Release Approaches for the Potential Treatment of Ulcerative Colitis, Journal of Biomaterials Applications (2022)
23. Ameliorative Effect of Galantamine on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2019)
24. Comparative Study of Berberis Vulgaris Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats, Iranian Journal of Pharmaceutical Research (2011)
25. Potential Role of Oxidative Stress on the Pathophysiology of Neuropathic Pain in the Inflammatory Diseases, Journal of Advances in Medical and Biomedical Research (2023)
26. Rosemary and Its Protective Potencies Against Covid-19 and Other Cytokine Storm Associated Infections: A Molecular Review, Mediterranean Journal of Nutrition and Metabolism (2021)
27. Validation and Optimization of Experimental Colitis Induction in Rats Using 2, 4, 6-Trinitrobenzene Sulfonic Acid, Research in Pharmaceutical Sciences (2012)
28. Anti-Inflammatory Effect of Ondansetron Through 5-Ht 3 Receptors on Tnbs-Induced Colitis in Rat, EXCLI Journal (2012)
29. Evaluating Anti-Inflammatory Effect of Hydroalcoholic Extracts of Citrus Medica L. Pulp and Peel on Rat Model of Acute Colitis, Research Journal of Pharmacognosy (2023)
30. Evaluation of Anti-Ulcerative Effect of Eryngium Billardieri Extracts on Experimental Colitis in Rats, Physiology and Pharmacology (Iran) (2024)
31. Protective Effect of Two Extracts of Cydonia Oblonga Miller (Quince) Fruits on Gastric Ulcer Induced by Indomethacin in Rats, International Journal of Preventive Medicine (2017)
32. A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases, Advances in Experimental Medicine and Biology (2021)
33. Effects of Carum Carvi L. (Caraway) Extract and Essential Oil on Tnbs-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2013)
34. Effects of Extract and Essential Oil of Rosmarinus Officinalis L. on Tnbs-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2011)
35. Evaluation of Central and Peripheral Effects of Doxepin on Acetic Acid-Induced Colitis in Rat and the Involved Mechanisms, EXCLI Journal (2017)
36. Effect of Venlafaxine on Experimental Colitis in Normal and Reserpinised Depressed Rats, Research in Pharmaceutical Sciences (2015)
37. Anti-Inflammatory Effect of Volatile Oil and Hydroalcoholic Extract of Rosa Damascena Mill. on Acetic Acid-Induced Colitis in Rats, Research in Pharmaceutical Sciences (2015)
38. Anti-Inflammatory and -Apoptotic Effects of a Long-Term Herbal Extract Treatment on Dss-Induced Colitis in Mice Fed With High Ages-Fat Diet, Nutrition and Metabolism (2021)
39. Involvement of 5Ht3 Receptors in Anti-Inflammatory Effects of Tropisetron on Experimental Tnbs-Induced Colitis in Rat, BioImpacts (2013)
40. Effect of Salbutamol Against the Experimental Acute Colitis in Rat Model, Comparative Clinical Pathology (2017)
41. Protective Effect of Dizocilpine (Mk-801) on Tnbs-Induced Experimental Colitis in Mice, Iranian Journal of Pharmaceutical Research (2019)
42. Anti-Inflammatory Effect of Pycnocycla Spinosa Extract and Its Component Isoacetovanillone on Acetic Acid Induced Colitis in Rats, Research in Pharmaceutical Sciences (2015)
43. Anti-Inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats, Iranian Journal of Pharmaceutical Research (2016)
44. Protective Effect of Nanoparticles of Oleoresin of Pistacia Atlantica Var. Mutica Against Acetic Acid-Induced Ulcerative Colitis in Rats, Traditional and Integrative Medicine (2022)
45. Evaluation of Spasmolytic Effects of Naringenin on Ileum Contraction and Intestinal Charcoal Meal Transit: Involvement of Atp-Sensitive K+Channels, Journal of HerbMed Pharmacology (2022)
46. The Effect of Memantine on Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis in Mice, European Journal of Pharmacology (2016)
47. Anti-Inflammatory Effects of Alosetron Mediated Through 5-Ht3 Receptors on Experimental Colitis, Research in Pharmaceutical Sciences (2019)
48. A Study of the Effects of Cydonia Oblonga Miller (Quince) on Tnbs-Induced Ulcerative Colitis in Rats, Research in Pharmaceutical Sciences (2012)
49. Anti-Inflammatory Effect of Kelussia Odoratissima Mozaff. Hydroalcoholicextract on Acetic Acid- Induced Acute Colitis in Rats, Journal of Reports in Pharmaceutical Sciences (2014)
50. Anti-Inflammatory and Analgesic Properties of the Leaf Extracts and Essential Oil of Lavandula Angustifolia Mill., Journal of Ethnopharmacology (2003)