Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Impact of Poor Glycemic Control on Lipid Profile Variables in Children With Type 1 Diabetes Mellitus Publisher



Mostofizadeh N1 ; Hashemipour M1 ; Roostazadeh M1 ; Hashemidehkordi E1 ; Shahsanai A2 ; Reisi M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pediatric Endocrinology, Endocrine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Community and Family Medicine Department, Isfahan University of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Pediatric Pulmonology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Education and Health Promotion Published:2019


Abstract

Type 1 diabetes mellitus (T1DM) and its related comorbidities are considered an important health issue. This study aimed to evaluate the impact of glycemic control on lipid profile variables in children with T1DM. MATERIALS AND METHODS: This study included 274 children (≤19 years of age) with T1DM who had referred to the outpatient clinics of endocrinology in Emam-Hossein Hospital of Isfahan, Iran. Based on American Diabetes Association criteria, patients were divided into two groups including optimal glycemic control (OGC) and poor glycemic control (PGC). Mean lipid level and frequencies of lipid profile abnormalities between the two studied groups were compared. RESULTS: Mean age of the studied population was 13 ± 5.9 years and 133 (48.5%) were boys. A total of 162 (59.1%) and 112 (40.9%) patients had PGC and OGC, respectively. Hypercholesterolemia was the most common dyslipidemia in both groups (33 [29.1%] of OGC and 63 [39.1%] of PGC patients). The frequency of high low-density lipoprotein (LDL) was significantly higher in patients with PGC than those with OCG (P = 0.007). The frequencies of hypercholesterolemia, hypertriglyceridemia, and low levels of high-density lipoprotein were also higher in PGC group, but did not reach the significant threshold. CONCLUSION: It is suggested that glycemic control is in association with lipid profile abnormality in patients with T1DM. High LDL was significantly more frequent in patients with PGC than those with OGC. It is recommended to investigate the role of glycemic control on other cardiometabolic risk factors of T1DM patients. Our findings could be used for planning preventative strategies for reducing T1DM-related cardiovascular disease. © 2019 Journal of Education and Health Promotion Published by Wolters Kluwer - Medknow.
Related Docs
View other Related Docs
1. Control of Dyslipidemia Among Type 2 Diabetic Patients in Isfahan, 5 Years Follow-Up (1999-2003), Iranian Journal of Diabetes and Lipid Disorders (2007)
2. Low-Density Lipoprotein Cholesterol and Risk of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2018)
3. Factors Related to Glycemic Control in Children and Adolescents With Type 1 Diabetes Mellitus in Isfahan, Iran, Journal of Diabetes and Metabolic Disorders (2021)
4. Trends in Incidence Rates of Childhood Type 1 Diabetes Mellitus: A Retrospective Study in Isfahan Province, Iran, Journal of Diabetes Investigation (2023)
5. The Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in a Population-Based Sample of Overweight/Obese Children in the Middle East, Pediatric Diabetes (2010)
6. Lipid and Glucose Serum Levels in Children With Congenital Heart Disease, Journal of Tehran University Heart Center (2014)
7. The Effect of Quality of Care on Cardiovascular Risk Factors in Newly Diagnosed Diabetic Patients, International Journal of Preventive Medicine (2014)
8. Reference Values for Lipid Profile in Iranian Children and Adolescents: The Caspian-V Study, Lipids in Health and Disease (2020)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (67)
Mahin Hashemipour (23)
Other Related Docs
9. Assessment of Risk Factors for Type I Diabetes Mellitus: A Case-Control Study, Journal of Isfahan Medical School (2017)
10. Utility of Continuous Metabolic Syndrome Score in Assessing Risk of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Annals of Nutrition and Metabolism (2016)
11. The Prevalence of Cardiovascular Risk Factors in Patients With Type 1 Diabetes in Isfahan, Iran, Iranian Journal of Diabetes and Lipid Disorders (2007)
12. Prevalence and Risk Factors of Diabetes Mellitus in the Isfahan City Population (Aged 40 or Over) in 1993, Diabetes Research and Clinical Practice (1997)
13. Diabetes and Impaired Glucose Regulation in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran: Prevalence and Risk Factors, Review of Diabetic Studies (2007)
14. Prevalence and Risk Factors of Diabetes, Pre-Diabetes and Metabolic Syndrome in First-Degree Relatives of Patients With Type Ii Diabetes, Journal of Kerman University of Medical Sciences (2013)
15. People With Impaired Glucose Tolerance and Impaired Fasting Glucose Are Similarly Susceptible to Cardiovascular Disease: A Study in First-Degree Relatives of Type 2 Diabetic Patients, Annals of Nutrition and Metabolism (2010)
16. Cardiovascular Risk Factors in Relatives of Type 2 Diabetics With Normal Glucose Tolerance Test and Elevated One-Hour Plasma Glucose, Endokrynologia Polska (2010)
17. Metabolic Syndrome in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors, Metabolic Syndrome and Related Disorders (2007)
18. Comparison of Glycated Hemoglobin With Fasting Plasma Glucose in Definition of Glycemic Component of the Metabolic Syndrome in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2012)
19. Glycemic Control Among Iranian People With Type 2 Diabetes: A Systematic Review and Meta-Analysis, International Journal of Diabetes in Developing Countries (2023)
20. Is Family History of Premature Cardiovascular Diseases Appropriate for Detection of Dyslipidemic Children in Population-Based Preventive Medicine Programs? Caspian Study, Pediatric Cardiology (2006)
21. Comparison of Serum Apolipoprotein Levels of Diabetic Children and Healthy Children With or Without Diabetic Parents, Cholesterol (2012)
22. Low Levels of High-Density Lipoprotein Cholesterol Do Not Predict the Incidence of Type 2 Diabetes in an Iranian High-Risk Population: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2016)
23. Comparison of Dietary Intake Between Children With Type1 Diabetes Mellitus and Control Group, Iranian Journal of Diabetes and Lipid Disorders (2005)
24. Validity of Triglyceride–Glucose Index As an Indicator for Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
25. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
26. First Nationwide Study of the Prevalence of the Metabolic Syndrome and Optimal Cutoff Points of Waist Circumference in the Middle East: The National Survey of Risk Factors for Noncommunicable Diseases of Iran, Diabetes Care (2009)
27. Progression to Impaired Glucose Metabolism in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran, Diabetes/Metabolism Research and Reviews (2009)
28. Changes in Serum Lipid Profile of Obese or Overweight Children and Adolescents Following a Lifestyle Modification Course, ARYA Atherosclerosis (2012)
29. Variations in Diabetes Prevalence in Low-, Middle-, and High-Income Countries: Results From the Prospective Urban and Rural Epidemiological Study, Diabetes Care (2016)
30. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
31. Incidence of Metabolic Syndrome and Its Risk Factors Among Type 2 Diabetes Clinic Attenders in Isfahan, Iran, Endokrynologia Polska (2012)
32. Metabolic Syndrome in First Degree Relatives of Patients With Type 2 Diabetes: Incidence and Risk Factors, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2011)
33. Associations Between Higher Egg Consumption During Pregnancy With Lowered Risks of High Blood Pressure and Gestational Diabetes Mellitus, International Journal for Vitamin and Nutrition Research (2018)
34. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
35. Prevalence of Metabolic Syndrome According to Atpiii and Idf Criteria in the Iranian Population, Koomesh (2012)
36. Effect of Potato Consumption As a High Glycemic Index Food on Pre-Diabetes Adult Patients, Pakistan Journal of Medical Sciences (2013)
37. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
38. Comparison Common Equations for Ldl-C Calculation With Direct Assay and Developing a Novel Formula in Iranian Children and Adolescents: The Caspian V Study, Lipids in Health and Disease (2020)
39. Glucose and Lipid-Related Indicators in Relation to Elevated Alanine Aminotransferase in a Pediatric Population, Journal of Pediatric Endocrinology and Metabolism (2024)
40. Prevalence and Related Risk-Factors of Peripheral Neuropathy in Children With Insulin-Dependent Diabetes Mellitus, Journal of Research in Medical Sciences (2013)
41. Comparison of Body Mass Index With Abdominal Obesity Indicators and Waist-To-Stature Ratio for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Obesity Research and Clinical Practice (2010)
42. Obesity and Metabolic Syndrome Among a Representative Sample of Iranian Adolescents, Southeast Asian Journal of Tropical Medicine and Public Health (2012)
43. The Association Between Glycemic Index, Glycemic Load and Total Carbohydrate Intake and Risk of Premature Coronary Artery Disease: Iran Premature Coronary Artery Disease Study (Ipad) - a Case-Control Study, Nutrition, Metabolism and Cardiovascular Diseases (2024)
44. A Personalised Diet Study: The Interaction Between Apoa2 −265T > C Polymorphism and Dietary Inflammatory Index on Oxidative and Inflammatory Markers and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study, International Journal of Clinical Practice (2021)
45. Glucose and the Risk of Hypertension in First-Degree Relatives of Patients With Type 2 Diabetes, Hypertension Research (2015)
46. The Association of Hypertriglyceridemic Waist Phenotype With Type 2 Diabetes Mellitus Among Individuals With First Relative History of Diabetes, Journal of Research in Medical Sciences (2011)
47. Prevalence of Total Cholesterol in Iran: Systematic Review and Meta-Analysis, Journal of Mazandaran University of Medical Sciences (2015)
48. Nutraceuticals in Hyperlipidemic Children: A Systematic Review and Meta-Analysis, International Journal of Pediatrics (2016)
49. The Effects of Macronutrient Intake on the Risk of Pre-Diabetes in First- Degree Relatives of Patients With Type 2 Diabetes, Journal of Isfahan Medical School (2014)
50. First Report on the Lipid Profile Late After Kawasaki Disease in Iranian Children, International Journal of Preventive Medicine (2014)