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Efficacy of Preladenant in Improving Motor Symptoms in Parkinson's Disease: A Systematic Review and Meta-Analysis Publisher



Karimi MA1 ; Ghajari A2 ; Khademi R3 ; Etemadi MH4 ; Firouz NS5 ; Mohammadvand B6 ; Janeshin K1, 7 ; Darvishi A8 ; Asgarzadeh S9 ; Sadatmadani SF10 ; Abbasalizadeh M11 ; Shendi ZJ8 ; Kohnehshahri AA12 ; Deravi N13 Show All Authors
Authors
  1. Karimi MA1
  2. Ghajari A2
  3. Khademi R3
  4. Etemadi MH4
  5. Firouz NS5
  6. Mohammadvand B6
  7. Janeshin K1, 7
  8. Darvishi A8
  9. Asgarzadeh S9
  10. Sadatmadani SF10
  11. Abbasalizadeh M11
  12. Shendi ZJ8
  13. Kohnehshahri AA12
  14. Deravi N13
  15. Mazhari SA14
  16. Aziz M15
  17. Bidares M15
  18. Belbasi M16
  19. Naziri M6
  20. Motlagh HA17
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of pharmacy Mashhad University of medical science, Mashhad, Iran
  3. 3. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Students Research Committee, School of Medicine, Shahrekord University of Medical Science, Shahrekord, Iran
  5. 5. Department of Psychology, University of Guilan, Rasht, Iran
  6. 6. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  8. 8. School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Neurology, Urumia Medical Science University, Urumia, Iran
  10. 10. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Student Research Committee, Faculty of Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
  13. 13. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  14. 14. Student Research Committee, Azerbaijan Medical University, Baku, Azerbaijan
  15. 15. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  16. 16. Students research committee, School of pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  17. 17. Bushehr University of Medical Sciences, Bushehr, Iran

Source: IBRO Neuroscience Reports Published:2024


Abstract

Background: Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by dopamine depletion and severe motor impairments. Preladenant, an adenosine A2 receptor antagonist, is an investigational treatment for PD. This systematic review and meta-analysis aimed to critically evaluate the efficacy of Preladenant in improving motor symptoms in patients with PD. Methods: A comprehensive literature search was conducted in PubMed, Embase, and Cochrane Central Register of Controlled Trials from inception to March 2023, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Randomized controlled trials (RCTs) comparing Preladenant with placebo in PD patients were included. The primary outcome was the change in daily ON time without troublesome dyskinesia. Secondary outcomes included the change in daily OFF time and adverse events. The risk of bias was assessed using the Cochrane Risk of Bias tool. Results: Four RCTs with a total of 2097 PD patients were included. Pooled analysis showed that Preladenant could generally increase daily ON time (pooled effect 0.15 and 95 % CI: −0.19–0.48) and reduce daily OFF time (pooled effect −0.04 and 95 % CI: −0.43–0.36) compared to placebo, however it was not significant. The included studies had moderate to high heterogeneity. No significant differences in adverse events were observed between Preladenant and placebo. Conclusion: This meta-analysis suggests that Preladenant may improve motor fluctuations in PD patients by increasing ON time and reducing OFF time. However, the high heterogeneity among studies warrants further large-scale, high-quality RCTs to confirm these findings and establish the long-term safety and efficacy of Preladenant in PD management. © 2024
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