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Severe Cognitive Dysfunction in a Patient With Polyendocrinopathy Publisher Pubmed



Dastjerdi MS1, 2 ; Aminorroaya A1 ; Amini M1 ; Ashrafi F1 ; Kazemi F1 ; Saadatnia M1 ; Mottaghi P1 ; Emami A1
Authors
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Authors Affiliations
  1. 1. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Endocrine and Metabolism Research Center, Sedigheh Tahereh Medical Research Complex, Isfahan, Khorram Street, Iran

Source: Experimental and Clinical Endocrinology and Diabetes Published:2007


Abstract

Background: Polyglandular Autoimmune syndromes (PGAs) or polyendocrinopathies are immune mediated multiple endocrine gland failure sometimes accompanied by nonendocrine autoimmune disorders with varieties of presentations. Case report: We describe a case of a middle aged man with severe cognitive dysfunction, brain atrophy, adrenal insufficiency, hypothyroidism, renal failure, thrombocytopenia, and positive antiphospholipid antibodies, with significant renal and cognitive improvement after hormone replacement. Conclusions: PGAs may present with a broad spectrum of manifestations related to different organs like nervous,renal.cardiac and hematopoietic systems, sometimes challenging both to physician and the patient. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart.