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Effect of Short Hydration on Cisplatin-Induced Nephrotoxicity in Cancer Patients: A Retrospective Study



Ashrafi F1, 2 ; Ebrahimi Z3 ; Nematbakhsh M4, 5
Authors
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Authors Affiliations
  1. 1. Hematology and Medical Oncology Division, Internal Medicine Department, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2017

Abstract

Background: The aim of this study was to evaluate the protective role of short hydration against nephrotoxicity induced by cisplatin (CDDP). Materials and Methods: Twenty-two patients (13 men and 9 women) under CDDP therapy were enrolled in this retrospective study between 2009 and 2014. The CDDP was given in 500 ml of isotonic solution, and before and after CDDP administration, the patients received 10mEq potassium chloride15% and 1gr magnesium sulfate in 1000 ml isotonic saline. Renal parameters were evaluated on the first day of each cycle of CDDP therapy. Results: Median cumulative CDDP dose was 465 mg/m2. Based on renal parameters, the prevalence of CDDP-induced nephrotoxicity (CIN) was 22.7%, while no hypokalemia and hypomagnesemia were observed. Conclusion: Short hydration accompanied with potassium chloride and magnesium sulfate may decrease the risk of CIN. © 2017 International Journal of Hematology-Oncology and Stem Cell Research, All Right Reserved.
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