Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Zinc Supplementation on Quality of Life and Sleep Quality in Young Women With Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial Publisher Pubmed



Jafari F1 ; Tarrahi MJ2 ; Farhang A1 ; Amani R1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Archives of Gynecology and Obstetrics Published:2020


Abstract

Introduction: Premenstrual syndrome is a prevalent disorder affecting a large number of women in their reproductive ages. Nutritional importance of zinc has been known for a long time and studies have shown that zinc can positively affect psychological disorders. Purpose: The aim of this study was to evaluate the effects of zinc supplementation on quality of life and sleep quality of young women diagnosed with premenstrual syndrome. Methods: This randomized, double-blind, placebo-controlled trial was carried out on 60 young university women that were allocated into two groups of intervention who took 30 mg/day of elemental zinc or placebo for three months. Pre- and post-intervention, participants completed the questionnaires of quality of life and Pittsburgh sleep quality. Results: After supplementation, quality of life score in the intervention group was increased (+ 9.185 ± 7.29, P < 0.001), however, in comparison with the control group, results were not significant; Physical aspects of quality of life score were significantly enhanced (+ 5.55 ± 3.71 vs. + 0.13 ± 2.87, P < 0.001). Sleep quality was marginally improved just in the zinc group (− 1.48 ± 4.12, P = 0.07). Conclusion: Zinc supplementation for 12 weeks had beneficial effects on physical aspects of quality of life in young women with premenstrual syndrome. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Related Docs
View other Related Docs
1. Effect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women With Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Biological Trace Element Research (2020)
2. The Efficacy and Safety of Zinc Gluconate Supplementation on Quality of Life, Sleep Quality, and Serum Albumin in Hemodialysis Patients: A Randomized Clinical Trial, European Journal of Integrative Medicine (2022)
3. The Association Between Dietary Zinc Intake and Health Status, Including Mental Health and Sleep Quality, Among Iranian Female Students, Biological Trace Element Research (2021)
4. The Effect of Zinc Supplementation on Brain Derived Neurotrophic Factor: A Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2021)
5. Association of Mood Disorders With Serum Zinc Concentrations in Adolescent Female Students, Biological Trace Element Research (2017)
6. Association Between Sleep Duration and Sleep Quality With Sugar and Sugar-Sweetened Beverages Intake Among University Students, Sleep and Breathing (2021)
7. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients With Type 2 Diabetes Mellitus: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis, Biological Trace Element Research (2024)
8. Omega-3 in the Subjective Betterment of Mood and Sleep Disturbances Induced by Hormone Therapy in Women With Breast Cancer: A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial, Sleep and Vigilance (2024)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (11)
Reza Amani (9)
Other Related Docs
9. Zinc and Copper Status in Children With High Family Risk of Premature Cardiovascular Disease, Annals of Saudi Medicine (2002)
10. The Effect of Auriculotherapy on Improving Sleep Quality in Postmenopausal Women Aged 45-60 Years: A Clinical Trial Study, Journal of Education and Health Promotion (2022)
11. Sleep Disorders During Pregnancy and Postpartum Depression: A Systematic Review and Meta-Analysis, International Journal of Developmental Neuroscience (2021)
12. Effect of Melatonin Supplementation on Sleep Quality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Neurology (2022)
13. The Effects of Zinc Acetate Capsule on the Intensity of Primary Dysmenorrhea: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Iranian Journal of Obstetrics, Gynecology and Infertility (2016)
14. Association Between Patterns of Nutrient Intake and Circulating Vitamin D With Sleep Status Among Iranian Adults, Scientific Reports (2023)
15. A Systematic Review and Meta-Analysis on the Prevalence of Zinc Deficiency in Iranian Population, Journal of Pediatrics Review (2023)
16. Association Between Sleep Quality and Postpartum Depression, Journal of Research in Medical Sciences (2016)
17. Is Vitamin D Status Associated With Depression, Anxiety and Sleep Quality in Pregnancy: A Systematic Review, Advanced Biomedical Research (2020)
18. Circadian Rhythm Sleep Disorders in Patients With Multiple Sclerosis and Its Association With Fatigue: A Case-Control Study, Journal of Research in Medical Sciences (2013)
19. Percentile Values of Serum Zinc Concentration and Prevalence of Its Deficiency in Iranian Children and Adolescents: The Caspian-V Study, Journal of Pediatric Endocrinology and Metabolism (2020)
20. Dietary Insulinemic Potential, Sleep Quality and Quantity in Iranian Adults: Yazd Health Study and Tamyz Study, BMC Nutrition (2023)
21. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
22. Low Serum Zinc Level in Depression, Journal of Research in Medical Sciences (2006)
23. Clinical Effectiveness of Zinc Supplementation on the Biomarkers of Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
24. Can Vitamin B6 Help to Prevent Postpartum Depression? a Randomized Controlled Trial, International Journal of Preventive Medicine (2021)
25. The Association Between Vitamin D and Premenstrual Syndrome: A Systematic Review and Meta-Analysis of Current Literature, Journal of the American College of Nutrition (2019)
26. Effects of Zinc Supplementation on Subscales of Anorexia in Children: A Randomized Controlled Trial, Pakistan Journal of Medical Sciences (2014)
27. The Effect of Zinc Supplementation on Blood Pressure: A Systematic Review and Dose–Response Meta-Analysis of Randomized-Controlled Trials, European Journal of Nutrition (2020)
28. The Association Between Serum Magnesium and Premenstrual Syndrome: A Systematic Review and Meta-Analysis of Observational Studies, Biological Trace Element Research (2019)
29. Zinc Status and Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2019)
30. The Effect of Cognitive Behavioural Psycho-Education on Premenstrual Syndrome and Related Symptoms, Journal of Psychiatric and Mental Health Nursing (2013)
31. Dietary Patterns Are Associated With Premenstrual Syndrome: Evidence From a Case-Control Study, Public Health Nutrition (2020)
32. The Association Between Carotenoid Intake, Mental Health, and Sleep Quality Among University Students, Sleep and Breathing (2022)
33. The Effect of Dracocephalum Extract on Sleep Quality in Post-Menopausal Women: A Randomized Placebo-Controlled Trial, Iranian Journal of Psychiatry (2022)
34. Zinc Nutritional Status, Mood States and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome: A Case–Control Study, Scientific Reports (2022)
35. Evaluating the Effects of Vitamin D and Vitamin E Supplement on Premenstrual Syndrome: A Randomized, Double-Blind, Controlled Trial, Iranian Journal of Nursing and Midwifery Research (2016)
36. Effect of Melatonin Supplementation on Body Composition and Blood Pressure in Adults: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trial, Heliyon (2024)
37. Effect of Zinc Supplementation on Glycemic Biomarkers: An Umbrella of Interventional Meta-Analyses, Diabetology and Metabolic Syndrome (2024)
38. Effects of Zinc Supplementation on Inflammatory Biomarkers and Oxidative Stress in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Trace Elements in Medicine and Biology (2021)
39. Sleep Deprivation Is Associated With Lower Diet Quality Indices and Higher Rate of General and Central Obesity Among Young Female Students in Iran, Nutrition (2012)
40. Effect of Calcium and Vitamin B1 on the Severity of Premenstrual Syndrome: A Randomized Control Trial, International Journal of Pharmacy and Technology (2016)
41. Zinc and Its Importance for Human Health: An Integrative Review, Journal of Research in Medical Sciences (2013)
42. Effect of Zinc Supplementation on Markers of Insulin Resistance, Oxidative Stress, and Inflammation Among Prepubescent Children With Metabolic Syndrome, Metabolic Syndrome and Related Disorders (2010)
43. Investigating the Effectiveness of Mindfulness Education on the Happiness of Women With Premenstrual Syndrome (Pms) Using Social Media: An Educational Study, Current Women's Health Reviews (2025)
44. The Relationship Between Disturbing Thoughts (Rumination, Worry) and Sleep Quality of Pregnant Mothers Referring to Health Centers Affiliated to Isfahan University of Medical Sciences 2019, Iranian Journal of Obstetrics, Gynecology and Infertility (2021)
45. The Effect of Zinc Supplementation on Lipid Profiles in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials, Advances in Nutrition (2023)
46. The Effect of Zinc Supplementation in Children With Attention Deficit Hyperactivity Disorder: A Systematic Review and Dose-Response Meta‑Analysis of Randomized Clinical Trials, Critical Reviews in Food Science and Nutrition (2022)
47. Effect of Prenatal Zinc Supplementation on Adipose Tissue-Derived Hormones and Neonatal Weight, Height and Head Circumference in Women With Impaired Glucose Tolerance Test: Randomized Clinical Controlled Trial, International Journal of Diabetes in Developing Countries (2019)
48. Effect of Zinc Supplementation on Mortality in Under 5-Year Children: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, European Journal of Nutrition (2022)
49. Does the Serum Zinc Level Affect the Quality of Life in Dialysis Patients? a Report From Iran, Nephro-Urology Monthly (2024)
50. Magnesium, Iron, and Zinc Supplementation for the Treatment of Attention Deficit Hyperactivity Disorder: A Systematic Review on the Recent Literature, International Journal of Preventive Medicine (2015)