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Factors Affecting Thrombocytopenia in Patients With Pesticide Intoxication Publisher



Gheshlaghi F ; Heydari S ; Feizi A ; Haddad S ; Shafiee H ; Meamar R ; Eizadimood N
Authors

Source: SN Comprehensive Clinical Medicine Published:2025


Abstract

Objective: This study aimed to investigate the factors affecting the occurrence of thrombocytopenia in patients due to pesticide intoxication. Methods: A cross-sectional study was conducted from 2016 to 2021. Data were collected from patients admitted with acute pesticide poisoning, focusing on demographics, intoxication features, clinical outcomes, and laboratory findings. Patients were classified into three groups based on the day of platelet reduction: first day, second day, and third day onwards. Severity of platelet reduction was measured. Statistical analysis included descriptive statistics, comparative analysis, and logistic regression [odd ratio (OR), 95% confidence interval (CI)]. Results: Of the 235 patients included, the majority were male (76.4%), with insecticides being the most frequent pesticide encountered. All patients had reduced platelet counts, but at different days and severity levels. Higher mortality rates and longer hospital stays were observed in the group with the presentation of thrombocytopenia on the third day or later. When comparing the third day to the first day, the administration of vitamin C medication [OR (95% CI), 7.664 (1.093–53.747), p = 0.04] and the use of pantoprazole medication [OR (95% CI), 3.08 (1.257–7.543), p = 0.014] were found to impact thrombocytopenia occurrence. Patients who were admitted to the intensive care unit had a 2.6-fold higher probability of developing thrombocytopenia [OR (95% CI), 2.635 (1.11–6.25), p = 0.02]. There was no significant difference in the odds of more severe thrombocytopenia based on onset timing. Conclusion: This study sheds light on factors associated with the occurrence of thrombocytopenia, emphasizing the need for targeted interventions and further research to improve patient outcomes. © 2025 Elsevier B.V., All rights reserved.