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Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency Publisher Pubmed



Yazdani R1, 2 ; Fatholahi M3 ; Ganjalikhanihakemi M1 ; Abolhassani H2, 4 ; Azizi G5 ; Hamid KM6, 7 ; Rezaei N8 ; Aghamohammadi A2
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran
  3. 3. Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran
  4. 4. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at the Karolinska University Hospital Huddinge, Stockholm, Sweden
  5. 5. Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Immunology Department, School of Public Health, Tehran University of Medical Sciences-International Campus (TUMS-IC), Tehran, Iran
  7. 7. Immunology Department, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran

Source: Molecular Immunology Published:2016


Abstract

Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD. © 2016 Elsevier Ltd.
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