Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response

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Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response Publisher Pubmed

Hombachklonisch S¹ ; Mehrpour M^{2, 3} ; Shojaei S^{1, 4} ; Harlos C^{5, 6} ; Pitz M^{5, 6} ; Hamai A^{2, 3} ; Siemianowicz K⁷ ; Likus W⁸ ; Wiechec E⁹ ; Toyota BD¹⁰ ; Hoshyar R^{11, 12} ; Seyfoori A¹³ ; Sepehri Z^{1, 14} ; Ande SR¹⁵ Show All Authors

Hombachklonisch S¹
Mehrpour M^{2, 3}
Shojaei S^{1, 4}
Harlos C^{5, 6}
Pitz M^{5, 6}
Hamai A^{2, 3}
Siemianowicz K⁷
Likus W⁸
Wiechec E⁹
Toyota BD¹⁰
Hoshyar R^{11, 12}
Seyfoori A¹³
Sepehri Z^{1, 14}
Ande SR¹⁵
Khadem F¹⁶
Akbari M¹³
Gorman AM^{17, 18}
Samali A^{17, 18}
Klonisch T^{1, 6}
Ghavami S^{1, 19}

Show Affiliations

1. Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
2. Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Paris, F-75993, France
3. Universite Paris Descartes-Sorbonne Paris Cite, Paris, F-75012, France
4. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Science, Isfahan, Iran
5. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
6. Research Institute of Oncology and Hematolog, CancerCare Manitoba, Winnipeg, MB, Canada
7. Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
8. Department of Anatomy, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland
9. Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
10. Division of Neurosurgery, Department of Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
11. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
12. Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
13. Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada
14. Internal Medicine Department, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
15. Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
16. Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
17. Apoptosis Research Centre, National University of Ireland, Galway, Ireland
18. School of Natural Sciences, National University of Ireland, Galway, Ireland
19. Health Policy Research Centre, Shiraz Medical University of Medical Science, Shiraz, Iran

Source: Pharmacology and Therapeutics Published:2018

Abstract

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of brain tumors remains a challenge. This is particularly true for the most frequent and fatal adult brain tumor, glioblastoma (GB). Upon diagnosis, the average survival time of GB patients remains only approximately 15 months. The alkylating drug temozolomide (TMZ) is routinely used in brain tumor patients and induces apoptosis, autophagy and unfolded protein response (UPR). Here, we review these cellular mechanisms and their contributions to TMZ chemoresistance in brain tumors, with a particular emphasis on TMZ chemoresistance in glioma stem cells and GB. © 2017 Elsevier Inc.

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Style	Citing Format
MLA	Hombachklonisch S, et al.. "Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response." Pharmacology and Therapeutics, vol. 184, no. , 2018, pp. 13-41.
APA	Hombachklonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, Likus W, Wiechec E, Toyota BD, Hoshyar R, Seyfoori A, Sepehri Z, Ande SR, Khadem F, Akbari M, Gorman AM, Samali A, Klonisch T, Ghavami S (2018). Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response. Pharmacology and Therapeutics, 184(), 13-41.
Chicago	Hombachklonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, et al.. "Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response." Pharmacology and Therapeutics 184, no. (2018): 13-41.
Harvard	Hombachklonisch S et al. (2018) 'Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response', Pharmacology and Therapeutics, 184(), pp. 13-41.
Vancouver	Hombachklonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, et al.. Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response. Pharmacology and Therapeutics. 2018;184():13-41.
BibTex	@article{ author = {Hombachklonisch S and Mehrpour M and Shojaei S and Harlos C and Pitz M and Hamai A and Siemianowicz K and Likus W and Wiechec E and Toyota BD and Hoshyar R and Seyfoori A and Sepehri Z and Ande SR and Khadem F and Akbari M and Gorman AM and Samali A and Klonisch T and Ghavami S}, title = {Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response}, journal = {Pharmacology and Therapeutics}, volume = {184}, number = {}, pages = {13-41}, year = {2018} }
RIS	TY - JOUR AU - Hombachklonisch S AU - Mehrpour M AU - Shojaei S AU - Harlos C AU - Pitz M AU - Hamai A AU - Siemianowicz K AU - Likus W AU - Wiechec E AU - Toyota BD AU - Hoshyar R AU - Seyfoori A AU - Sepehri Z AU - Ande SR AU - Khadem F AU - Akbari M AU - Gorman AM AU - Samali A AU - Klonisch T AU - Ghavami S TI - Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response JO - Pharmacology and Therapeutics VL - 184 IS - SP - 13 EP - 41 PY - 2018 ER -

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