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First Report on Path Analysis for Cardiometabolic Components in a Nationally Representative Sample of Pediatric Population in the Middle East and North Africa (Mena): The Caspian-Iii Study Publisher Pubmed



Kelishadi R1 ; Motlagh ME4, 5 ; Roomizadeh P2 ; Abtahi SH2 ; Qorbani M8, 10 ; Taslimi M7 ; Heshmat R9 ; Aminaee T6 ; Ardalan G1, 6 ; Poursafa P3 ; Karimi M8
Authors
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Authors Affiliations
  1. 1. Pediatrics Department, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Medical Studts. Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Environment Department, Environment Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Pediatrics Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Bureau of Population, Family and School Health, Ministry of Health and Medical Education, Tehran, Iran
  6. 6. Office of School Health, Ministry of Health and Medical Education, Tehran, Iran
  7. 7. Bureau of Health and Fitness, Ministry of Education, Tehran, Iran
  8. 8. Department of Public Health, Alborz University of Medical Sciences, Karaj, Iran
  9. 9. Epidemiology Department, Chronic Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Epidemiology Department, Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Annals of Nutrition and Metabolism Published:2013


Abstract

Background/Aims: This study aimed to test a potential model of the relationship between various cardiometabolic risk factors including obesity, unhealthy diet, low physical activity, dyslipidemia, and high blood pressure in a large population-based sample of children and adolescents. Methods: In this nationwide study, a representative sample of 5,528 students aged 10-18 years was selected by multistage random cluster sampling from 27 provinces of Iran. Demographic, anthropometric, biological, and biochemical factors were determined. Structural equation modeling (path analysis) was applied to evaluate the causal relationship between these variables. Results: The mean age of study participants was 14.7 ± 2.41 years and the mean body mass index (BMI) was 19.4 ± 4.1. Higher socioeconomic status was directly associated with unhealthy diet, low physical activity and BMI in both sexes. Age had a positive direct effect on low physical activity in both sexes. BMI showed the greatest direct effect on total cholesterol, triglyceride, low-density lipoprotein cholesterol, and mean arterial pressure in comparison with the direct effects of unhealthy diet and low physical activity. BMI was associated negatively with high-density lipoprotein cholesterol in both groups. Conclusions: No previous study has used path analysis for determining the interactions examined in this study among a nationally representative sample of children in the Middle East and North Africa (MENA). The results of this study underline the imperative need for the weight loss and lifestyle change from childhood as the first-line preventive strategy for metabolic syndrome and noncommunicable diseases. © 2013 S. Karger AG, Basel.
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