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Increased Irf4 Expression in Isolated B Cells From Common Variable Immunodeficiency (Cvid) Patients Publisher Pubmed



Afsharghasemlou S1 ; Esmaeil N1 ; Sherkat R2 ; Yazdani R3 ; Abbasirad F1 ; Ganjalikhanihakemi M1, 2 ; Rezaei A1
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran

Source: Allergologia et Immunopathologia Published:2019


Abstract

Background: Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by low serum levels of immunoglobulins (Igs) and recurrent infection. In most CVID patients, a defect in the differentiation of B cells into plasma cells has been observed. Several factors play an important role in the proliferation and differentiation of B cells, including IRF4 and XBP1 transcription factors. Methods: In the present study we investigated the expression of IRF4 and XBP1 in the B-cells of CVID and healthy controls (HCs). For this purpose, we assessed the expression of IRF4 and XBP1 at both mRNA and protein levels by real time-PCR and flow cytometry, respectively. Results: We found that IRF4 expression was significantly increased in CVID patients compared with controls. Although the XBP1 protein level was lower in patients in comparison to controls, this difference was not significant. Conclusion: Taken together, increased IRF4 expression could be involved in defective functions of B cells in CVID patients. © 2018 SEICAP
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