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Prevalence of Minor Β-Thalassemia Based on Rbc Indices Among Final Suspected Individuals in Premarital Screening Program Referred to Genetic Laboratories



Moafi A1 ; Valian S2 ; Nikyar Z1 ; Zeinalian M3 ; Momenzadeh M3 ; Rahgozar S4
Authors
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Authors Affiliations
  1. 1. Department of Pediatric Hematology-Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Division of Genetics, Department of Biology, University of Isfahan, Isfahan, Iran
  3. 3. The Office of Health Services, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Division of Molecular and Cell Biology, Department of Biology, University of Isfahan, Isfahan, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2010

Abstract

Introduction: The current study evaluated the value of red blood cell (RBC) indices and the corresponding cutoffpoints for β-thalassemia control programs in Iran. Materials and Methods: 1,150 individuals (575 couples) with low RBC indices and normal hemoglobin A2 who had been referred to the Genetic Centre of Isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2006-2008. β-thalassemia mutations were evaluated. Results: β-thalassemia was identified in 67.8% of the cases with both mean corpuscular volume (MCV) less than 78fl and mean corpuscular hemoglobin (MCH) less than 26 pg. However, 4.1% of the individuals with 78≤ MCV≤ 80 tested positive for thalassemia. MCV showed a higher diagnostic reliability than MCH. However, the accompaniment of MCH<26 with MCV<78 increased the risk of thalassemia 35 times. A significant association was found between the prevalence of minor β-thalassemia and educational levels, raceand familial relationships. Conclusion: According to the results of this study, it seems that MCV=80fl can be used as a proper cut-off point for the screening of minor β-thalassemia. Although in the present study MCV was found to have a higher diagnostic reliability than MCH, MCH <26 along with MCV are very helpful indices for the counselor physician to estimate the risk of minor β-thalassemia more accurately.
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