Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Study of the Biologic Behavior of Odontogenic Keratocyst and Orthokeratinaized Odontogenic Cyst Using Tgf-Alpha and P53 Markers Publisher Pubmed



Deyhimi P1 ; Hashemzadeh Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dentistry School, Isfahan University of Medical Sciences, Iran
  2. 2. Oral and Maxillofacial Pathology Department, Dentistry School, Rafsanjan University of Medical Sciences, Iran

Source: Pathology Research and Practice Published:2014


Abstract

Odontogenic keratocyst (OKC) is an aggressive cyst, and its recurrence rate is higher than that of other odontogenic cysts. Orthokeratinized odontogenic cyst (OOC) is less aggressive than OKC, but bears the probability of carcinomatous changes. In this study, we evaluated the expression and intensity of P53 and TGF-alpha in order to compare the biologic behavior or probable carcinomatous changes of these two cysts.In this cross-sectional study, 15 OKC and 15 OOC were stained immunohistochemically for P53 and TGF-alpha using the Novolink polymer method. Then, all slides were examined by an optical microscope with 400× magnification, and the stained cells in the basal and parabasal layers were counted. Finally, the results were analyzed by the Mann-Whitney and Wilcoxon tests (P-value. <. 0.05).The difference between the expression of P53 and TGF alpha in the basal layer of OKC and OOC was not statistically significant (P-value. >. 0.05), but the expression of P53 and TGF-alpha in the parabasal layer in OKC was statistically higher compared to OOC (P<. 0.05).Considering the known role of P53 and TGF-alpha in malignant changes and the higher expression of P53 and TGF-alpha in OKC compared to those in OOC, the probability of carcinomatous changes was higher in OKC than in OOC. © 2013 Elsevier GmbH.
Related Docs
View other Related Docs
1. Investigation of Clinicopathological Parameters Alongside With P53 Expression in Primary and Recurrent Keratocysticodontogenic Tumours, Malaysian Journal of Pathology (2014)
2. Evaluating Histopathological Factors of Predicting the Recurrence Rate of Odontogenic Keratocyst, Dental Research Journal (2023)
3. Kerathocyst Odontogenic Tumor: Importance of Selection the Best Treatment Modality and a Periodical Follow-Up to Prevent From Recurrence: A Case Report and Literature Review, International Journal of Preventive Medicine (2013)
4. Immunohistochemical Expression of Collagen Iv and Mmp9 in Odontogenic Cysts and Tumors, Biosciences Biotechnology Research Asia (2015)
5. Expression of Bcl-2 and Epithelial Growth Factor Receptor Proteins in Keratocystic Odontogenic Tumor in Comparison With Dentigerous Cyst and Ameloblastoma, Dental Research Journal (2015)
6. Evaluation of Transforming Growth Factor Beta 1 Expression in Ameloblastoma, Calcifying Odontogenic Cyst and Odontogenic Keratocyst, Journal of Orofacial Sciences (2020)
7. Study of Extrinsic Apoptotic Pathway in Oral Lichen Planus Using Tnfr 1 and Fasl Immunohistochemical Markers and Tunel Technique, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology (2018)
8. Determination of the Relationship Between Basal Cell Carcinoma and Human Papilloma Virus, Based on Immunohistochemistry Staining Method, Indian Journal of Dermatology (2009)
Experts (# of related papers)
View all Related Experts
Gholamreza Jahanshahi (2)
Foruz Keshani (2)
Other Related Docs
9. Investigation of P53 Codon 72 Polymorphism in Patients With Nonmelanoma Skin Cancers in Isfahan, Journal of Isfahan Medical School (2011)
10. Determination of P53 Expression in Basal Cell Carcinoma Tissues and Adjacent Nontumoral Epidermis From Sun-Exposed Areas of the Head and Neck, Archives of Iranian Medicine (2006)
11. Comparison of Immunohistochemical Expression of Cd10 in Keratocystic Odontogenic Tumor and Ameloblastoma, Dental Research Journal (2016)
12. Conservative Treatment Protocol of Keratocystic Odontogenic Tumor: Report of a Case With Nevoid Basal Cell Carcinoma Syndrome and Literature Review, Journal of Maxillofacial and Oral Surgery (2015)