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Alk-Positive Histiocytosis Involving the Cavernous Sinus: A Deceptive Radiologic Mimic of Meningioma Publisher



Alizadeh M1 ; Ravindran A2 ; Chkheidze R3 ; Goyal G4 ; Hosseini M5 ; Shobeiri P6 ; Shafieioun A7 ; Khalafi M8 ; Shahidi R9 ; Sotoudeh H10 ; Singhal A11
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Authors Affiliations
  1. 1. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Pathology, University of Alabama at Birmingham (UAB), Birmingham, AL, United States
  3. 3. Department of Neuropathology, University of Alabama at Birmingham (UAB), Birmingham, AL, United States
  4. 4. Department of Medicine- Hematology and Oncology, University of Alabama at Birmingham (UAB), Birmingham, AL, United States
  5. 5. Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States
  6. 6. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  10. 10. Department of Radiology and Neurology, University of Alabama at Birmingham (UAB), 619 19th St S, Birmingham, 35294, AL, United States
  11. 11. Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, AL, United States

Source: Radiology Case Reports Published:2023


Abstract

Anaplastic lymphoma kinase (ALK)-positive histiocytosis is an uncommon condition, recently considered a separate condition from other histiocytosis by WHO 5th edition. It can involve intracranial structures. This manuscript describes a case of ALK-positive histiocytosis of the cavernous sinus, focusing on the radiologic and pathologic presentation of the entity. Our case had MRI manifestations mimicking meningioma, metastasis, and Langerhans histiocytosis. On CT imaging, benign osseous remodeling of the cavernous sinus was detected, which can be helpful in differentiating it from more common meningioma. © 2023
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