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Polyurethane Nanocomposite Impregnated With Chitosan-Modified Graphene Oxide As a Potential Antibacterial Wound Dressing Publisher Pubmed



Najafabadi SAA1 ; Mohammadi A2 ; Kharazi AZ1
Authors
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Authors Affiliations
  1. 1. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran

Source: Materials Science and Engineering C Published:2020


Abstract

In this study, a polyurethane nanocomposite film (PU/CS-GO) was synthesized by incorporating chitosan-modified GO nanosheets (CS-GO) into PU matrices. The successful synthesis of unmodified GO and CS-GO nanosheets was confirmed by FTIR, XRD, Raman, SEM, EDS, and TGA analyses. In comparison with polyurethane nanocomposite containing unmodified graphene oxide (PU/GO), the effect of the modification of GO with chitosan on different properties such as morphological, thermal, thermo-mechanical, wettability, antibacterial, and biocompatibility properties was evaluated by various analyses including XRD, FE-SEM, TGA, DMTA, contact angle, antibacterial studies, and MTT assay. FE-SEM images exhibited better dispersion of CS-GO nanosheets within polyurethane matrices compared to GO nanosheets. According to DMTA results, PU/CS-GO showed a higher glass transition temperature (Tg) and storage modulus values than PU/GO sample. Based on antibacterial and MTT assays, in comparison with PU/GO, the PU/CS-GO nanocomposite demonstrated better biocompatibility and also antibacterial activity against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. Based on results, the PU/CS-GO nanocomposite can be suggested as a promising material for antibacterial wound dressing. © 2020 Elsevier B.V.
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