Preparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film Publisher



Bahrinajafi R¹ ; Eghbali M² ; Peykanpour M² ; Mirzaei HR³ Show Affiliations
Source: Journal of Reports in Pharmaceutical Sciences Published:2013

Abstract

A new type of drug delivery system known as mucoadhesive film has been developed for oral thrush treatment. Due to comfortable use of this drug delivery system, this would be encouragingly utilized, especially in babies and patients under chemotherapy. Nystatinmucoadhesive film (NMF) is a polymeric film which is adhered to front upper gum and back to the upper lip and releases the drug within 5-6 hours in desired concentration. Because of sustained-release nature and permanent contact of drug with infectious agent of Candida albicans, the disease healing process would happen more rapidly, and in the meantime the patients can go on with their usual activities such as eating, drinking and talking without feeling the film in their mouth cavity. NMF was prepared using Eudragit RL100 and HPMC as film-forming constituents, and glycerin, propylene glycol and poly ethylene glycol 400 as plasticizers, according to casting method. Finally, physical appearance, weight, in vitro drug release rate and adhesion were assessed. with respect to considered parameters, prepared films with HPMC did not show uniform appearance; however, prepared films with Eudragit RL100 showed more desirable results and later showed longer drug release time with approximate time of 3.5 hours. Prepared NMF with dimensions of 2×1 Cm containing 10 mg nystatin using Eudragit RL100 polymer with mixture of glycerin, propylene glycol as plasticizer, not only showed desirable pharmaceutics characteristics but also exponential value (n) of 0.779 showed non-Fickian behavior of drug release. © 2013 by Kermanshah University of Medical Sciences.