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Investigation of Association Between Genetic Diversities in Yq11.223 Region With Men Infertility in Isfahan Population



Motovalibashi M1 ; Hojati Z1 ; Rezaei Z1 ; Hemmati S2
Authors
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Authors Affiliations
  1. 1. Division of Genetics, Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
  2. 2. Department of Oncology and Radiotherapy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2011

Abstract

Background: Infertility is one of the important human problems. One of the main genetic factors of infertility is the deletions in the chromosome Y' which is reported in 10-15% of men with severe azoospermia and oligospermia. Three regions in azoospermia factor (AZFa), (AZFb) and (AZFc) are specified as the spermatogenetic regions. In this study we investigated the effect of changes in Yq11.223 (DAZ) region in chromosome Y on infertility. Methods: In this study the blood samples of 100 infertile men who referred to the Infertility Center of Isfahan and 100 healthy people, as the control group were taken. The genomic DNA was extracted from blood samples. The analyses were performed by applying the polymerase chain reaction (PCR) technique in AZF region of Yq11.223. Finding: In this study 70 azoospermia and 30 oligospermia patients were investigated. The deletions in AZF region of Yq11.223 were recognized in 7 azoospermia patients but there were not detected in oligospermia patients and the control group. It was also observed that the intensity of bands were changed comparing between azoospermia patients. Conclusion: Deletion frequency in the region of Yq11.223 was observed in 7 of 100 (7%) infertile Oligospermia and Azoospermia men. Our results confirm the effect of DAZ in the man's infertility.
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