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Serum Leptin Level Has a Positive Correlation With Bmi and Creatinine Clearance in Capd Patients Publisher Pubmed



Seirafian S1 ; Momeni A2 ; Taheri S1 ; Mortazavi M1 ; Paknahad Z3
Authors
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Authors Affiliations
  1. 1. Department of Nephrology, Alzahra Hospital, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Division of Nephrology, Hajar Hospital, Shahrekord University of Medical Science, 8816754633-Shahrekord, Parastar Avenue, Iran
  3. 3. Health Faculty, Isfahan University of Medical Science, Isfahan, Iran

Source: Bratislava Medical Journal Published:2012


Abstract

Objective: In a cross sectional study, 75 patients (42 males and 33 females) on continuous ambu-latory peritoneal dialysis (CAPD) were enrolled from October 2007 to February 2008. Serum levels of leptin, albumin, triglyceride, dialysis adequacy (total KT/V), renal creatinine clearance (Cr Cl), mid arm circumference and demographic findings were measured in all patients. Results: The mean age of patients was 53 14.76. The history of hemodialysis was seen in 23 patients. Mean serum leptin level in women and men were 27 23µg/l and 16 13µg/l respectively. A significant correlation of serum leptin level with body mass index (BMI) (p<0.001) and renal Cr Cl (p<0.001) was found. There was no significant correlation of serum leptin level with KT/V duration of renal failure serum triglycerides (TG) serum low density lipoprotein (LDL) cholesterol and mid arm circumference (p>0.05). Conclusions: To our knowledge, this is probably the first study to report that serum leptin level has a direct posi-tive correlation with renal Cr Cl in CAPD patients. This may explain the increase in mortality in patients with lower serum leptin levels (Tab. 2, Fig. 2, Ref. 25). Full Text in PDF www.elis.sk.
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