Highly Selective Hkust-1@Sio2@Mno2 Nanorods for Rapid Dispersive Solid Phase Extraction of Paraben Preservatives in Cosmetics Publisher

Summary: Can cosmetic parabens be measured more cleanly? A modified HKUST-1 adsorbent recovered six parabens in cosmetic samples with good precision and greener extraction. #AnalyticalChemistry #GreenScience

Shirani M ; Ozalp O ; Sepahi S ; Basij M ; Nazifi S M R ; Soylak M
Source: Microchemical Journal Published:2026

Abstract

In this study, HKUST-1 was functionalized with silicon dioxide (SiO2) and α‑manganese dioxide nanorods (HKUST-1@SiO2@MnO2 NRs), as a novel and high-performance nanostructure adsorbent. To consider the accuracy of the synthetized structure, Fourier-Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray Spectroscopy, and X-Ray diffraction were used. HKUST-1@SiO2@MnO2 NRs was applied for dispersive μ-solid phase extraction (DμSPE) of six commonly used parabens including methyl-, ethyl-, propyl-, butyl-, isobutyl-, benzyl- parabens in cosmetics prior to high performance liquid chromatography with photodiode array detector. The linear ranges of 0.1–500 and 0.1–750 (μg Kg−1) were obtained for lipstick, mascara, face powder, face-hand moisturizing cream, baby shampoo, whitening cream, and hair gel. The limits of detection and limits of quantification values in the range of 0.027–0.033 (μg Kg−1) and 0.09–0.12 (μg Kg−1) were obtained for the target parabens in cosmetics. The intra-day precision (repeatability) and the inter-day precision (reproducibility) (%) were ≤2.2 and ≤2.6, respectively. The applicability of the method was investigated in which the recoveries (%) of 91.6–100.0 were obtained. Moreover, the application of green metrics evaluation tools including BAGI, AGREE, AGREEprep, and CaFRI affirmed the greenness of the proposed method. © 2026 Elsevier B.V.