Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Atmospheric Concentrations of Polycyclic Aromatic Hydrocarbons With Their Urinary Metabolites in Children and Adolescents Publisher Pubmed



Poursafa P1 ; Amin MM2 ; Hajizadeh Y3 ; Mansourian M4 ; Pourzamani H3 ; Ebrahim K3 ; Sadeghian B5 ; Kelishadi R6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Environment Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Environmental Health Engineering, Environment Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Hezarjerib Ave, Isfahan, Iran
  3. 3. Department of Environmental Health Engineering, Environment Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Isfahan Department of Environment, Isfahan, Iran
  6. 6. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Environmental Science and Pollution Research Published:2017


Abstract

This study aims to determine the atmospheric concentrations of particulate matter 2.5 (PM2.5)-bounded polycyclic aromatic hydrocarbons (PAHs) and their association with their urinary metabolites in children and adolescents. This study was conducted from October 2014 to March 2016 in Isfahan, Iran. We measured 16 species of PAHs bounded to PM2.5 by gas chromatography mass spectrometry (GC/MS) from 7 parts of the city. Moreover, PAH urinary metabolites were measured in 186 children and adolescents, randomly selected from households. Urinary metabolites consisted of 1-hydroxy naphthalene (1-naphthol), 2-hydroxy naphthalene (2-naphthol), 9-hydroxy phenanthrene (9-phenanthrol), and 1-hydroxy pyrene using GC/MS. Considering the short half-lives of PAHs, we measured the metabolites twice with 4 to 6 months of time interval. We found that the ambient concentrations of PAHs were significantly associated with their urinary metabolites. 1-hydroxy naphthalene and 2-hydroxy naphthalene concentrations showed an increase of 1.049 (95% CI: 1.030, 1.069) and 1.047 (95% CI: 1.025, 1.066) for each unit increase (1 ng/m3) in ambient naphthalene. Similarly, 1-hydroxy pyrene showed an increase of 1.009 (95% CI: 1.006–1.011) for each unit increase (1 ng/m3) in ambient pyrene concentration after adjustment for body mass index, physical activity level, urinary creatinine, age, and sex. The association of urinary 9-hydroxyphenanthrene and ambient phenantherene was significant in the crude model; however after adjustment for the abovementioned covariates, it was no more significant. We found significant correlations between exposure to ambient PM2.5-bounded PAHs and their urinary excretion. Considering the adverse health effects of PAHs in the pediatric age group, biomonitoring of PAHs should be underscored; preventive measures need to be intensified. © 2017, Springer-Verlag Berlin Heidelberg.
Related Docs
View other Related Docs
1. Association of Polycyclic Aromatic Hydrocarbons With Cardiometabolic Risk Factors and Obesity in Children, Environment International (2018)
2. Urinary Levels of Pah Metabolites in Pregnant Women and Their Correlation With Sociodemographic Factors and Pm2.5 Exposure in an Urban and a Suburban Area, Air Quality, Atmosphere and Health (2021)
3. Is There Any Association Between Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and Thyroid Hormone Levels in Children and Adolescents?, Environmental Science and Pollution Research (2018)
4. A Systematic Review on the Effects of Polycyclic Aromatic Hydrocarbons on Cardiometabolic Impairment, International Journal of Preventive Medicine (2017)
5. Association of Polycyclic Aromatic Hydrocarbons Urine Metabolites With Type 1 Diabetes, Journal of Diabetes Research (2023)
6. Investigating the Concentration and Health Risks of Particulate-Bound Polycyclic Aromatic Hydrocarbons in Isfahan’S Ambient Air; [بررسی غلظت و خطر سلامتی هیدروکربن های آروماتیک چند حلقه ای باند شده به ذرات معلق در هوایآزاد شهر اصفهان], Iranian Journal of Health and Environment (2024)
7. Cytotoxicity and Genotoxicity of Fine Particulate Matter (Pm2.5): A Polluted City Experiencing Middle East Dust Events, Air Quality, Atmosphere and Health (2024)
8. Environmental and Biological Monitoring of Exposures to Vocs in a Petrochemical Complex in Iran, Environmental Science and Pollution Research (2018)
Experts (# of related papers)
View all Related Experts
Karim Ebrahimpour (16)
Yaghoub Hajizadeh (13)
Other Related Docs
9. Biomonitoring of Unmetabolized Polycyclic Aromatic Hydrocarbons (Pahs) in Urine of Waterpipe/Cigarette Cafe Workers, Environmental Science and Pollution Research (2023)
10. Association of Urinary Phthalate Metabolites Concentrations With Body Mass Index and Waist Circumference, Environmental Science and Pollution Research (2018)
11. Urinary Trans, Trans-Muconic Acid Is Not a Reliable Biomarker for Low-Level Environmental and Occupational Benzene Exposures, Safety and Health at Work (2017)
12. The Association of Prenatal Exposure to Benzophenones With Gestational Age and Offspring Size at Birth, Environmental Science and Pollution Research (2022)
13. Characteristics and Health Risk Assessment of Polycyclic Aromatic Hydrocarbons Associated With Dust in Household Evaporative Coolers, Environmental Pollution (2020)
14. Association of Urinary Concentrations of Phthalate Metabolites With Cardiometabolic Risk Factors and Obesity in Children and Adolescents, Chemosphere (2018)
15. Ambient Variations of Benzene and Toluene in Yazd, Iran, Using Geographic Information System, Journal of Mazandaran University of Medical Sciences (2016)
16. Evaluation of Exposure to Parabens in Iranian Women and Its Association With Personal Care Products Using Behavior, Human and Ecological Risk Assessment (2020)
17. The Necessity of Screening of Individuals With Suspected Inherited Metabolic Disorders for Early Diagnosis and Treatment of Related Diseases, Journal of Isfahan Medical School (2013)
18. Relationship of Urinary Phthalate Metabolites With Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents, Journal of Environmental and Public Health (2021)
19. Indoor Contaminants From Hardcopy Devices: Characteristics of Vocs in Photocopy Centers, Atmospheric Environment (2012)
20. Urinary Concentrations of Parabens Amongst Iranian Adults and Their Associations With Socio-Demographic Factors, Journal of Environmental Health Science and Engineering (2020)
21. Exposure to Phthalates and Bisphenol a Is Associated With Higher Risk of Cardiometabolic Impairment in Normal Weight Children, Environmental Science and Pollution Research (2019)
22. Monitoring of Urinary Phthalate Metabolites Among Pregnant Women in Isfahan, Iran: The Persian Birth Cohort, Journal of Environmental Health Science and Engineering (2019)
23. Urinary Concentrations of Parabens in a Population of Iranian Adolescent and Their Association With Sociodemographic Indicators, Archives of Environmental Contamination and Toxicology (2020)
24. Heavy Metals and Polycyclic Aromatic Hydrocarbons in Sludge From Three Industrial Wastewater Treatment Plants of the Industrial Parks of Isfahan Province, International Journal of Environmental Health Engineering (2015)
25. Urinary 1-Hydroxypyrene As a Biomarker of Carcinogenic Polycyclic Aromatic Hydrocarbons in Iranian Carbon Anode Plant Workers, International Journal of Environmental Health Engineering (2012)
26. Association of Exposure to Fine Particulate Matter and Risk Factors of Non-Communicable Diseases in Children and Adolescents, International Journal of Pediatrics (2017)
27. Cancer Risk Assessment for Workers Exposed to Pollution Source, a Petrochemical Company, Iran, Iranian Journal of Public Health (2020)
28. Establishment of Reference Ranges and Profile of Urinary Organic Acids in Different Pediatric Age Groups of the Iranian Healthy Population, Journal of Isfahan Medical School (2014)
29. Urinary Profile of Pahs and Related Compounds in Women Working in Beauty Salons, Science of the Total Environment (2022)
30. Effects of Particle Size, Seasonal Variation, and Acid Aging on the Oxidative Potential of Urban and Industrial Airborne Pm in Isfahan Metropolis, Iran, Environmental Pollution (2025)
31. Spatio-Temporal Variations, Ozone and Secondary Organic Aerosol Formation Potential, and Health Risk Assessment of Btex Compounds in East of Azerbaijan Province, Iran, Urban Climate (2023)
32. Association Between Prenatal Phthalate Exposure and Anthropometric Measures of Newborns in a Sample of Iranian Population, Environmental Science and Pollution Research (2021)
33. Atmospheric Pollutants in an Iranian Industrial Metropolis: Spatiotemporal Analyses Associated With Health Risks and Photochemical Pollutions, Iranian Journal of Toxicology (2023)
34. Monitoring the Level of Urinary Metabolites of Toluene and Xylene in Pregnant Women in Isfahan and Khansar and Their Relationship With Demographic Factors and Air Quality Index, International Journal of Environmental Health Engineering (2023)
35. Data on Concentrations of Polycyclic Aromatic Hydrocarbons (Pahs) in Roasted and Fried Chicken – a Case Study: Bushehr, Iran, Data in Brief (2018)
36. Association of Benzene Exposure With Insulin Resistance, Sod, and Mda As Markers of Oxidative Stress in Children and Adolescents, Environmental Science and Pollution Research (2018)
37. Urinary Paraben Concentrations and Their Implications for Human Exposure in Iranian Pregnant Women, Environmental Science and Pollution Research (2020)
38. Determination of Polycyclic Aromatic Hydrocarbons Concentration in Eight Brands of Black Tea Which Are Used More in Iran, International Journal of Environmental Health Engineering (2013)