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Ischemic Stroke in Young Asian Women: Risk Factors, Subtypes and Outcome Publisher Pubmed



Wasay M1 ; Kaul S2 ; Menon B3 ; Venketasubramanian N5 ; Gunaratne P6 ; Khalifa A7 ; Poungvarin N8 ; Saadatnia M9 ; Gan RN5 ; Dai A10 ; Mehndiratta MM4
Authors
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Authors Affiliations
  1. 1. Department of Medicine/Neurology, Aga Khan University, Karachi 74800, Stadium Road, Pakistan
  2. 2. Nizam Institute of Medical Sciences, Hyderabad, India
  3. 3. Sri Venkateswara Institute of Medical Sciences, Tirupati, India
  4. 4. GB Pant Hospital, New Delhi, India
  5. 5. National Neuroscience Institute, Singapore, Singapore
  6. 6. National Hospital of Sri Lanka, Colombo, Sri Lanka
  7. 7. Damascus Hospital, Damascus, Syrian Arab Republic
  8. 8. Mahidol University, Bangkok, Thailand
  9. 9. Isfahan University of Medical Science, Isfahan, Iran
  10. 10. Gaziantep University, Gaziantep, Turkey

Source: Cerebrovascular Diseases Published:2010


Abstract

Background and Objective: The objective of our study was to describe risk factors, mechanisms and outcome of young Asian women with ischemic stroke. Methods: Twelve tertiary-care centers in 8 Asian countries participated. Women aged 15-45 years were included if they had an ischemic stroke supported by neuroimaging. Data on age, risk factor history, stroke mechanism and discharge status were collected. Results: A total of 958 subjects were included, their mean age was 34 years. Large-vessel thrombosis comprised 24%, cerebral venous thrombosis 21%, cardioembolism 19% and small-vessel thrombosis 15%. The stroke risk factors included hypertension (29%), diabetes (14%), pregnancy (11%), valvular heart disease (10%) and cigarette smoking (3%). Anemia was found in 42%, and mortality was 4%; at discharge, 17% had modified Rankin score (mRS) >4 and 83% mRS 0-3. Conclusion: Unlike among Caucasians, large-vessel thrombosis, cerebral venous thrombosis and cardioembolism are common among young Asian women with stroke. A high proportion are pregnancy-related. More studies are needed. Copyright © 2010 S. Karger AG.
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