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Evaluating Sex Hormone Levels in Reproductive Age Women With Multiple Sclerosis and Their Relationship With Disease Severity



Foroughipour A1 ; Norbakhsh V1 ; Najafabadi SH2 ; Meamar R3, 4
Authors
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Authors Affiliations
  1. 1. Department of Midwifery, Islamic Azad University, Najaf Abad Branch, Isfahan, Iran
  2. 2. Isfahan Medical Students Research Center (IMSRC), Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Neurosciences Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Medical Science, Islamic Azad University, Najaf Abad Branch, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2012

Abstract

Background: Sex-related differences in the severity of multiple sclerosis (MS) could be influenced by the sex hormones. Materials and Methods: This cohort (historical) study evaluated the sex hormone levels during menstrual cycle and their correlation with disease severity in MS. Result: Patients with MS had significantly lower testosterone, dehydroepiandrosterone sulfate and prolactin levels than controls in the follicular and luteal phase but lower estradiol levels only in the follicular phase. A positive correlation coefficient between follicle stimulating hormone and disease severity, and a reverse correlation with estradiol were found. Conclusion: The hormone-related modulation of disease severity supports the suggestion that sex hormones play a role in MS disease.
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