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Study of Mazef, Sam, and Phd-Doc Putative Toxin-Antitoxin Systems in Staphylococcus Epidermidis Publisher Pubmed



Behrooz SK1 ; Lida L2 ; Ali S1 ; Mehdi M3 ; Rasoul M1 ; Elnaz O1 ; Farid BT4 ; Gholamreza I1
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Medicine, Department of Microbiology, Urmia University of Medical Sciences, Urmia, Iran
  3. 3. Department of Bacteriology and Virology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of medicine, Department of Parasitology and Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Acta Microbiologica et Immunologica Hungarica Published:2018


Abstract

Today, to replace the antibacterial targets to overcome antibiotic resistance, toxin-antitoxin (TA) system is noticeable, where the unstable antitoxin neutralizes the stable toxin and protects the bacteria against the toxic effects. The presence and expression of TA genes in clinical and non-clinical strains of Staphylococcus epidermidis were investigated in this study. After identification of three TA pairs (mazEF, sam, and phd-doc) via existing databases (earlier, there has been no information in the case of S. epidermidis isolates), the presence and expression of these pairs were investigated by PCR and q-PCR, respectively. We detected three TA modules in all antibiotic sensitive and resistant isolates. In addition, q-PCR analysis revealed that the transcripts were produced from the three TA modules. This study showed the significant prevalence of these systems in pathogenic bacteria and they were equally found in both oxacillin-resistant and oxacillin-susceptible bacteria. The high prevalence of three systems can make them suitable as potential targets for antibiotic therapy. © 2018 Akademiai Kiado, Budapest.
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