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The Effects of Gabapentin on Improvement of Consciousness Level in Patients With Traumatic Brain Injury: A Randomized Clinical Trial



Najafi MR1 ; Abrishamkar S2 ; Sonbolestan SA3 ; Hamrah H4
Authors
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Authors Affiliations
  1. 1. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Student of Medicine, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2012

Abstract

BACKGROUND: Traumatic brain injury (TBI) is known as one of the most important causes of mortality in middle-aged population. The aim of this study was to evaluate the effects of gabapentin in improvement of consciousness level in these patients. METHODS: This randomized clinical trial was performed in March 2008 to September 2009. A total number of 60 patients from neurology clinics of Kashani Hospital (Isfahan, Iran) were randomly divided into two groups of 30 subjects as the case and control groups. The groups were respectively treated with 300 mg gabapentin and placebo twice a day for two weeks. The electroencephalogram (EEG), Glasgow Outcome Scale (GOS), and Glasgow Coma Scale (GCS) findings were evaluated in all patients before and one week after the intervention. RESULTS: The mean values of GCS and GOS before and after the treatment were not significantly different between the groups. This study showed significant changes in EEG patterns after treatment with gabapentin. CONCLUSIONS: Gabapentin might not be suggested for management of unconsciousness due to TBI.
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