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The Tangled Web of Dyslipidemia and Cancer: Is There Any Association? Publisher



Neshat S1 ; Rezaei A2 ; Farid A3 ; Sarallah R4 ; Javanshir S4 ; Ahmadian S1 ; Chatrnour G5 ; Daneii P1 ; Heshmatghahdarijani K6
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Internal Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  3. 3. Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, School of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran
  5. 5. Department of Internal Medicine, New Jersey, United States
  6. 6. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Research in Medical Sciences Published:2022


Abstract

Cancer is a primary cause of mortality around the world and imposes a significant physiological, psychological, and financial burden on patients. Lipids regulate cell cycle progression and affect cell proliferation, migration, and apoptosis. Therefore, alterations in serum lipid levels might contribute to carcinogenesis. In this article, we review the relationships between triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels and different types of cancer. Then, we examine the association between cancer and familial hypercholesterolemia. Finally, we evaluate the impact of statins on different types of cancer. Increased total cholesterol has been reported to increase cellular proliferation and angiogenesis in tumors and inhibit apoptosis. Increased LDL-C has been reported to induce inflammation and increase susceptibility to oxidative damage. HDL-C has anti-oxidation, anti-inflammatory, and antiproliferative properties. Increased levels of serum TG can induce oxidative stress and a chronic inflammatory state and therefore contribute to the proliferation and progression of cancer cells. Statins decrease downstream products of cholesterol synthesis that are crucial in cell proliferation and growth. Thus, lipid components can have prognostic value in cancer and management of serum lipid levels through lifestyle changes and medical therapy can be beneficial in cancer prevention and treatment. © 2022 Journal of Research in Medical Sciences.
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