Effect of Peroxisome Proliferator-Activated Receptors on Cardiac Remodeling in Normal and Diabetic Rats



Salehi E¹ ; Khazaei M² ; Rashidi B³ Show Affiliations
Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Peroxisome proliferator-activated receptors (PPARs) have three isoforms: β/δ, γ and α. It is indicated that peroxisome proliferator-activated receptors have different effects on cardiovascular system. In this study, we investigated the effect of these receptors on cardiac remodeling in normal and diabetic rats. Methods: 60 male rats were divided equally into normal and diabetic groups and each group was divided equally into following groups; saline (control), fenofibrate 100 mg/kg/day, rosiglitazone 8 mg/kg/day, GW0742 1 mg/kg/day and bezafibrate 400 mg/kg/day. After 21 days, the left ventricles were removed and stained with Picro-Sirius Red. Findings: Collagen content in left ventricles of diabetic animals (9.00 ± 1.27) were higher than controls (5.00 ± 1.13) (P < 0.05). Administration of peroxisome proliferator-activated receptor agonists did not alter interstitial fibrosis in control and diabetic groups (P > 0.05). Conclusion: Although, peroxisome proliferator-activated receptor agonists have several effects on cardiovascular system; it seems that they cannot alter cardiac remodeling in normal and diabetic animals. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.