Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy Publisher Pubmed

Hosseini R¹ ; Sarvnaz H² ; Arabpour M³ ; Ramshe SM⁴ ; Asefkabiri L⁵ ; Yousefi H⁶ ; Akbari ME⁵ ; Eskandari N¹

Show Affiliations

1. Department of Immunology School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Immunology School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Genetics School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Student Research Committee, Department of Medical Genetics, School of Medicine Shahid, Beheshti University of Medical Sciences, Tehran, Iran
5. Surgical Oncologist Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, United States

Source: Molecular Cancer Published:2022

Abstract

Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation. Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment. However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed. © 2022, The Author(s).

Related Docs

View other Related Docs

1. The Roles of Tumor-Derived Exosomes in Altered Differentiation, Maturation and Function of Dendritic Cells, Molecular Cancer (2021)

2. Small Extracellular Vesicle Tgf-Β in Cancer Progression and Immune Evasion, Cancer Gene Therapy (2023)

3. Blockade of Exosome Release Alters Her2 Trafficking to the Plasma Membrane and Gives a Boost to Trastuzumab, Clinical and Translational Oncology (2023)

4. Advances in Natural Killer Cell Therapies for Breast Cancer, Immunology and Cell Biology (2023)

5. Effect of Plasma-Derived Exosomes of Refractory/Relapsed or Responsive Patients With Diffuse Large B-Cell Lymphoma on Natural Killer Cells Functions, Cell Journal (2020)

6. Targeting Immune Checkpoints: How to Use Natural Killer Cells for Fighting Against Solid Tumors, Cancer Communications (2023)

7. Early Diagnosis of Breast and Ovarian Cancers by Body Fluids Circulating Tumor-Derived Exosomes, Cancer Cell International (2020)

8. Advances in Bioengineered Car T/Nk Cell Therapy for Glioblastoma: Overcoming Immunosuppression and Nanotechnology-Based Strategies for Enhanced Car T/Nk Cell Therapy, Bioengineering and Translational Medicine (2024)

Experts (# of related papers)

View all Related Experts

Mazdak Ganjalikhani Hakemi (5)

Nafiseh Esmaeil (4)

Other Related Docs

9. Modulation of the Immune System by Melatonin; Implications for Cancer Therapy, International Immunopharmacology (2022)

10. Engaging Stemness Improves Cancer Immunotherapy, Cancer Letters (2023)

11. The Nexus of Natural Killer Cells and Melanoma Tumor Microenvironment: Crosstalk, Chemotherapeutic Potential, and Innovative Nk Cell-Based Therapeutic Strategies, Cancer Cell International (2023)

12. Immune-Dysregulation Harnessing in Myeloid Neoplasms, Cancer Medicine (2024)

13. Recent Advancements to Engineer Mesenchymal Stem Cells and Their Extracellular Vesicles for Targeting and Destroying Tumors, Progress in Biophysics and Molecular Biology (2023)

14. Combination Therapy With Nivolumab (Anti-Pd-1 Monoclonal Antibody): A New Era in Tumor Immunotherapy, International Immunopharmacology (2022)

15. More Balance Toward Activating Receptors and Cytotoxic Activity of Nk Cells Ex Vivo Differentiated From Human Umbilical Cord Blood-Derived Cd34+ Stem Cells in Comparison With Peripheral Blood Nk Cells, Heliyon (2024)

16. Oncolytic Virotherapy Improves Immunotherapies Targeting Cancer Stemness in Glioblastoma, Biochimica et Biophysica Acta - General Subjects (2024)

17. Pathological Role of Inflammation in Ocular Disease Progress and Its Targeting by Mesenchymal Stem Cells (Mscs) and Their Exosome; Current Status and Prospect, Pathology Research and Practice (2023)

18. Optimization of in Vitro Expansion and Activation of Human Natural Killer Cells Against Breast Cancer Cell Line, Avicenna Journal of Medical Biotechnology (2020)

19. Genetically Engineered Mesenchymal Stem Cells: Targeted Delivery of Immunomodulatory Agents for Tumor Eradication, Cancer Gene Therapy (2020)

20. Investigating the Dynamic Interplay Between Cellular Immunity and Tumor Cells in the Fight Against Cancer: An Updated Comprehensive Review, Iranian Journal of Blood and Cancer (2024)

21. The Expression of Natural Killer Group 2D Molecule on Peripheral Blood T-Lymphocytes in Metastatic and Non-Metastatic Colorectal Cancer Patients in Comparison to Healthy Controls, Journal of Isfahan Medical School (2013)

22. Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities, Current Cancer Drug Targets (2022)

23. Immune Evader Cancer Stem Cells Direct the Perspective Approaches to Cancer Immunotherapy, Stem Cell Research and Therapy (2022)

24. The Role of Nk and Nkt Cells in the Pathogenesis and Improvement of Multiple Sclerosis Following Disease-Modifying Therapies, Health Science Reports (2022)

25. Strong Capacity of Differentiated Pd-L1 Car-Modified Ucb-Cd34+ Cells and Pd-L1 Car-Modified Ucb-Cd34+-Derived Nk Cells in Killing Target Cells and Restoration of the Anti-Tumor Function of Pd-1-High Exhausted T Cells, Stem Cell Research and Therapy (2024)

26. A Novel Car Expressing Nk Cell Targeting Cd25 With the Prospect of Overcoming Immune Escape Mechanism in Cancers, Frontiers in Oncology (2021)

27. The Therapeutic Effect of Mscs and Their Extracellular Vesicles on Neuroblastoma, Progress in Biophysics and Molecular Biology (2024)

28. The Decrease in Nkg2d+ Natural Killer Cells in Peripheral Blood of Patients With Metastatic Colorectal Cancer, Bratislava Medical Journal (2015)

29. Flip-Flops of Natural Killer Cells in Autoimmune Diseases Versus Cancers: Immunologic Axis, Journal of Cellular Physiology (2019)

30. Immunotherapy a New Hope for Cancer Treatment: A Review, Pakistan Journal of Biological Sciences (2018)

31. Regenerative Medicine in Covid-19 Treatment: Real Opportunities and Range of Promises, Stem Cell Reviews and Reports (2021)

32. Anti-Egfr Bioengineered Bacterial Outer Membrane Vesicles As Targeted Immunotherapy Candidate in Triple-Negative Breast Tumor Murine Model, Scientific Reports (2023)

33. Mesenchymal Stem Cell-Released Oncolytic Virus: An Innovative Strategy for Cancer Treatment, Cell Communication and Signaling (2023)

34. Immunologic Tumor Microenvironment Modulators for Turning Cold Tumors Hot, Cancer Communications (2024)

35. Clinical Combinatorial Treatments Based on Cancer Vaccines: Combination With Checkpoint Inhibitors and Beyond, Current Drug Targets (2022)

Style	Citing Format
MLA	Hosseini R, et al.. "Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy." Molecular Cancer, vol. 21, no. 1, 2022, pp. -.
APA	Hosseini R, Sarvnaz H, Arabpour M, Ramshe SM, Asefkabiri L, Yousefi H, Akbari ME, Eskandari N (2022). Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy. Molecular Cancer, 21(1), -.
Chicago	Hosseini R, Sarvnaz H, Arabpour M, Ramshe SM, Asefkabiri L, Yousefi H, Akbari ME, Eskandari N. "Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy." Molecular Cancer 21, no. 1 (2022): -.
Harvard	Hosseini R et al. (2022) 'Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy', Molecular Cancer, 21(1), pp. -.
Vancouver	Hosseini R, Sarvnaz H, Arabpour M, Ramshe SM, Asefkabiri L, Yousefi H, et al.. Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy. Molecular Cancer. 2022;21(1):-.
BibTex	@article{ author = {Hosseini R and Sarvnaz H and Arabpour M and Ramshe SM and Asefkabiri L and Yousefi H and Akbari ME and Eskandari N}, title = {Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy}, journal = {Molecular Cancer}, volume = {21}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Hosseini R AU - Sarvnaz H AU - Arabpour M AU - Ramshe SM AU - Asefkabiri L AU - Yousefi H AU - Akbari ME AU - Eskandari N TI - Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy JO - Molecular Cancer VL - 21 IS - 1 SP - EP - PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract