Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of Soymilk and Probiotic Soymilk Effects on Serum High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in Diabetic Wistar Rats



Babashahi M1 ; Mirlohi M2 ; Ghiasvand R3 ; Azadbakht L3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Food Security Research Center AND Department of Food Science and Technology, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2015

Abstract

BACKGROUND: Soy milk (SM) and its fermented products are identified as rich sources of bioactive compounds helping to manage and to reduce the risk of chronic disease. This study aimed to compare the effects of SM and probiotic SM (PSM) consumption on serum low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in diabetic Wistar rats. METHODS: Probiotic SM was prepared by fermentation of the plain SM with a native strain of Lactobacillus plantarum. 20 streptozotocin-nicotinamide-induced diabetic Wistar rats were divided into two groups based on the type of administered SM: SM group and PSM group. The animals were fed with 1 ml/day of either soy or PSM for 21 days. The serum lipoprotein levels were analyzed at baseline and the end of the intervention period. RESULTS: HDL-C increased significantly in PSM group. Furthermore, this group showed more percent of change in increased HDL-C in compression with SM group (P < 0.050). Regarding LDL-C level, rats fed with SM was not significantly different from the PSM group (P > 0.050); though, this biomarker was reduced in both group. CONCLUSION: Probiotic SM could modulate blood lipoprotein levels. Thus, it may be considered in managing diabetes complications and atherosclerotic risks. © 2015 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Effects of Probiotic Soy Milk Fermented by Lactobacillus Plantarum A7 (Kc 355240) Added With Cuminum Cyminum Essential Oil on Fasting Blood Glucose Levels, Serum Lipid Profile and Body Weight in Diabetic Wistar Rats, International Journal of Preventive Medicine (2020)
2. The Effects of Soy Products on Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Clinical Trials, Advances in Nutrition (2022)
3. Soy and Cardio-Metabolic Abnormalities: An Update, Journal of Research in Medical Sciences (2008)
4. Reduction in Serum Lipid Parameters by Incorporation of a Native Strain of Lactobacillus Plantarum A7 in Mice, Iranian Journal of Diabetes and Lipid Disorders (2010)
5. Probiotic Supplementation for Management of Cardiovascular Risk Factors in Adults With Type Ii Diabetes: A Systematic Review and Meta-Analysis, Clinical Nutrition (2018)
6. Effects of Probiotics and Synbiotic on Lipid Profiles in Adults at Risk of Type 2 Diabetes: A Double-Blind Randomized Controlled Clinical Trial, Functional Foods in Health and Disease (2019)
7. Effect of Probiotic Soy Milk on Serum Levels of Adiponectin, Inflammatory Mediators, Lipid Profile, and Fasting Blood Glucose Among Patients With Type Ii Diabetes Mellitus, Probiotics and Antimicrobial Proteins (2017)
8. The Effect of Probiotic Fermented Milk Products on Blood Lipid Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2021)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (16)
Awat Feizi (11)
Other Related Docs
9. A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial on Probiotic Soy Milk and Soy Milk: Effects on Epigenetics and Oxidative Stress in Patients With Type Ii Diabetes, Genes and Nutrition (2015)
10. Effect of Cucurbita Ficifolia and Probiotic Yogurt Consumption on Blood Glucose, Lipid Profile, and Inflammatory Marker in Type 2 Diabetes, International Journal of Preventive Medicine (2016)
11. Effects of Probiotic Soy Milk on Lipid Panel in Type 2 Diabetic Patients With Nephropathy: A Double-Blind Randomized Clinical Trial, Progress in Nutrition (2018)
12. The Effects of Isolated Soy Protein, Isolated Soy Isoflavones and Soy Protein Containing Isoflavones on Serum Lipids in Postmenopausal Women: A Systematic Review and Meta-Analysis, Critical Reviews in Food Science and Nutrition (2020)
13. Probiotic Soy Beverages: A Functional Beverage on Lipid Profile, Oxidative Stress and Kidney Function: A Systematic Review of Randomized Controlled Trials, Nutrition and Food Science (2025)
14. Probiotic Supplementation in Diabetic Hemodialysis Patients Has Beneficial Metabolic Effects, Kidney International (2017)
15. Effects of Soy Consumption on Metabolic Parameters in Patients With Metabolic Syndrome: A Systematic Review and Meta-Analysis, EXCLI Journal (2021)
16. How Much in Vitro Cholesterol Reducing Activity of Lactobacilli Predicts Their in Vivo Cholesterol Function?, International Journal of Preventive Medicine (2013)
17. The Effects of Probiotic Supplementation on Markers of Blood Lipids, and Blood Pressure in Patients With Prediabetes: A Randomized Clinical Trial, International Journal of Preventive Medicine (2014)
18. Effect of Multispecies Probiotic Supplements on Metabolic Profiles, Hs-Crp, and Oxidative Stress in Patients With Type 2 Diabetes, Annals of Nutrition and Metabolism (2013)
19. The Effect of Pumpkin and Probiotic Yogurt Consumption Separately Or/And Simultaneously on Type Ii Diabetes, Journal of Isfahan Medical School (2014)
20. The Effect of Walnut Consumption on Lipid Profiles of the First-Degree Relatives of Type Two Diabetes Mellitus Patients (T2dm) With Prediabetes, Pakistan Journal of Medical Sciences (2013)
21. Effects of Securigera Securidaca Extract on Lipolysis and Adipogenesis in Diabetic Rats, Cholesterol (2014)
22. The Impact of Probiotic Soy Milk Consumption on Oxidative Stress Among Type 2 Diabetic Kidney Disease Patients: A Randomized Controlled Clinical Trial, Journal of Renal Nutrition (2017)
23. Effects of Fenugreek Seeds on Adipogenesis and Lipolysis in Normal and Diabetic Rats, Pakistan Journal of Biological Sciences (2014)
24. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
25. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
26. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
27. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
28. Soy Milk Consumption, Inflammation, Coagulation, and Oxidative Stress Among Type 2 Diabetic Patients With Nephropathy, Diabetes Care (2012)
29. Effects of Ferulago Angulata Extract on Serum Lipids and Lipid Peroxidation, Evidence-based Complementary and Alternative Medicine (2014)
30. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
31. Bilirubin, a Hepatoprotective Agent That Activates Sirt1, Pgc-1Α, And Ppar-Α, While Inhibiting Nf-Κb in Rats With Metabolic-Associated Fatty Liver Disease, Scientific Reports (2024)
32. The Effect of Probiotics on Lipid Profile & Anthropometric Indices in Diabetic Nephropathy; a Systematic Review and Meta-Analysis of Clinical Trials, Journal of Diabetes and Metabolic Disorders (2021)
33. Sustained Feeding of a Diet High in Fat Resulted in a Decline in the Liver's Insulin-Degrading Enzyme Levels in Association With the Induction of Oxidative and Endoplasmic Reticulum Stress in Adult Male Rats: Evaluation of 4-Phenylbutyric Acid, Heliyon (2024)
34. Dairy As a Functional Food in Cardiovascular Disease, Nutrients in Dairy and Their Implications for Health and Disease (2017)
35. Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Drug Targets (2023)
36. Effect of Non-Soy Legume Consumption on Inflammation and Serum Adiponectin Levels Among First-Degree Relatives of Patients With Diabetes: A Randomized, Crossover Study, Nutrition (2015)
37. The Protective Effects of Ziziphus Vulgaris L. Fruits on Biochemical and Histological Abnormalities Induced by Diabetes in Rats, Journal of Complementary and Integrative Medicine (2014)
38. Effects of Probiotic Supplementation in Patients With Type 2 Diabetes: Systematic Review and Meta-Analysis, Nutrition Reviews (2016)
39. Protective and Curative Effects of Unconjugated Bilirubin on Gene Expression of Lox-1 and Inos in the Heart of Rats Receiving High-Fat Diet and Low Dose Streptozotocin: A Histomorphometric Approach, Journal of Inflammation (United Kingdom) (2024)
40. Rice Bran Oil Decreases Total and Ldl Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Hormone and Metabolic Research (2016)
41. The Postprandial Effect of Apple Juice Intake on Some of the Biochemical Risk Factors of Atherosclerosis in Male Rabbit, Journal of Medicinal Plants Research (2009)
42. The Effects of Probiotic and Synbiotic Supplementation on Metabolic Syndrome Indices in Adults at Risk of Type 2 Diabetes: Study Protocol for a Randomized Controlled Trial, Trials (2017)
43. Does Fenugreek (Trigonella Foenum-Graecum) Seed Improve Inflammation, and Oxidative Stress in Patients With Type 2 Diabetes Mellitus? a Parallel Group Randomized Clinical Trial, European Journal of Integrative Medicine (2018)
44. The Effects of Wheat Germ Supplementation on Metabolic Profile in Patients With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial, Phytotherapy Research (2020)
45. Comparative Study of Anti-Diabetic Effects of Insulin, Epigenin and Salvia Mirzayanii Extract in Streptozotocin-Induced Diabetic Male Rats, Indian Journal of Biochemistry and Biophysics (2023)
46. Evaluation of Response Surface Methodology to Predict Optimum Growth Conditions for Lactobacillus Plantarum A7 (Kc 355240) in Probiotic Soy Milk Containing Essential Oil of Cuminum Cyminum, Recent Patents on Food, Nutrition and Agriculture (2016)
47. Diabetic Retinopathy Clinical Practice Guidelines: Customized for Iranian Population, Journal of Ophthalmic and Vision Research (2016)
48. Effects of Soy Milk Consumption on Inflammatory Markers and Lipid Profiles Among Non-Menopausal Overweight and Obese Female Adults, Journal of Research in Medical Sciences (2012)
49. Biochemical and Histopathological Study of the Anti-Hyperglycemic and Anti-Hyperlipidemic Effects of Cornelian Cherry (Cornus Mas L.) in Alloxan-Induced Diabetic Rats, Journal of Complementary and Integrative Medicine (2014)
50. Effect of Glycyrrhiza Glabra Extract on Aorta Wall Atherosclerotic Lesion in Hypercholesterolemic Rabbits, Pakistan Journal of Nutrition (2007)