Agr Typing of Staphylococcus Aureus Species Isolated From Clinical Samples in Training Hospitals of Isfahan and Shahrekord Publisher Pubmed



Javdan S¹ ; Narimani T² ; Shahini Shams Abadi M³ ; Gholipour A^{1, 4}
Source: BMC Research Notes Published:2019

Abstract

Objective: As an opportunistic pathogen, Staphylococcus aureus is associated with serious nosocomial infections and growing antimicrobial resistance against beta-lactams among S. aureus strains has become a global challenge. The current study was designed to investigate the presence of agr genes among S. aureus strains recovered from clinical samples in university hospitals of Isfahan and Shahrekord. Results: A total of 150 S. aureus isolates were screened by Disk diffusion method (DDM) and conventional PCR. The minimum (17.3%) and maximum (46%) antibiotic resistance rates were found in vancomycin and cefoxitin, respectively. The majority of our isolates were classified as agr type I followed by type II, type IV, and type III. The statistical analysis showed a significant correlation between agr type I and antibiotic resistance against cefoxitin and erythromycin (p = 0.04 and p = 0.03, respectively). Based on our findings, the agr typing could be considered an effective approach for molecular tracking of S. aureus infections. © 2019 The Author(s).