An Overview of the Role of Interleukin-8 in Colorectal Cancer Publisher Pubmed



Najdaghi S^{1, 2} ; Razi S^{1, 3} ; Rezaei N^{4, 5, 6} Show Affiliations
Source: Cytokine Published:2020

Abstract

Colorectal Cancer (CRC), a common malignancy, is developing globally among people. Mutagenic insults activate peripheral nucleated cells to secrete chemokines in order to cause an inflammatory state. Despite the presence of multi-retrieving factors, elevated production of minor cytokines may speed-up the sever stages of the baseline inflammation targeting normal compensatory mechanism. IL-8 is a pro-inflammatory cytokine that is believed to be up-regulated in CRC to proceed primary condition into tumor behavior via induction of proliferation, angiogenesis and metastasis. Here, we assess the role of IL-8 in every step of CRC from signaling pathway and formation to invasion and discuss around new perspective therapy that targets IL-8 to manage CRC worldwide incidence and survival rate, more precisely. © 2020 Elsevier Ltd