Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines

Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines Publisher Pubmed

Mohammadi Pour P¹ ; Yegdaneh A¹ ; Aghaei M² ; Ali Z³ ; Khan IA³ ; Ghanadian M⁴

Show Affiliations

1. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3. National Center for Natural Products Research, University of Mississippi, University, MS, United States
4. Department of Pharmacognosy, Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Natural Product Research Published:2022

Abstract

The steroidal and terpenoidal composition of Sinularia variabilis was investigated by chromatography methods. One new (1), and four known [gorgasta-5-en-3β-ol (2), ergosta-5-en-3β-ol (3), ergosta-5, 22(Z)-dien-3β-ol (4), 5,8-epidioxy-5α, 8α-ergosta-6, 22E-dien-3β-ol (5)] steroids, in addition to one known diterpenoidal alkaloid [sinulasulfone (6)] isolated for the first time from S. variabilis. If we named the 23-methylergostane core structure as sinustane, new compound (1) was elucidated as 16α,17α-epoxysinusta-5-en-3β–ol-20β-yl sulfate based on NMR and HR Mass data. It was submitted for cytotoxic activity evaluation against MCF-7 and MDA-MB-231 cell lines using MTT assay. Apoptosis induction was checked by flow cytometry (annexin V/propidium iodide) staining. To determine the production of reactive oxygen species, and the mitochondrial transmembrane potential (ΔΨm), the DCFDA, and JC‐1 probes were used in this study. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

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Mustafa Ghanadian (10)

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Style	Citing Format
MLA	Mohammadi Pour P, et al.. "Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines." Natural Product Research, vol. 36, no. 15, 2022, pp. 3796-3805.
APA	Mohammadi Pour P, Yegdaneh A, Aghaei M, Ali Z, Khan IA, Ghanadian M (2022). Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines. Natural Product Research, 36(15), 3796-3805.
Chicago	Mohammadi Pour P, Yegdaneh A, Aghaei M, Ali Z, Khan IA, Ghanadian M. "Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines." Natural Product Research 36, no. 15 (2022): 3796-3805.
Harvard	Mohammadi Pour P et al. (2022) 'Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines', Natural Product Research, 36(15), pp. 3796-3805.
Vancouver	Mohammadi Pour P, Yegdaneh A, Aghaei M, Ali Z, Khan IA, Ghanadian M. Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines. Natural Product Research. 2022;36(15):3796-3805.
BibTex	@article{ author = {Mohammadi Pour P and Yegdaneh A and Aghaei M and Ali Z and Khan IA and Ghanadian M}, title = {Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines}, journal = {Natural Product Research}, volume = {36}, number = {15}, pages = {3796-3805}, year = {2022} }
RIS	TY - JOUR AU - Mohammadi Pour P AU - Yegdaneh A AU - Aghaei M AU - Ali Z AU - Khan IA AU - Ghanadian M TI - Novel 16,17-Epoxy-23-Methylergostane Derivative From Sinularia Variabilis, a Soft Coral From the Persian Gulf, With Apoptotic Activities Against Breast Cancer Cell Lines JO - Natural Product Research VL - 36 IS - 15 SP - 3796 EP - 3805 PY - 2022 ER -

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