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Hiv-Related Atherosclerosis: State-Of-The-Art-Review Publisher Pubmed



Avagimyan A1 ; Pogosova N2 ; Kakturskiy L3 ; Sheibani M4, 5 ; Urazova O6 ; Trofimenko A7 ; Navasardyan G8 ; Jndoyan Z9 ; Abgaryan K10 ; Fogacci F9 ; Galli M10 ; Agati L11 ; Kobalava Z12 ; Shafie D13 Show All Authors
Authors
  1. Avagimyan A1
  2. Pogosova N2
  3. Kakturskiy L3
  4. Sheibani M4, 5
  5. Urazova O6
  6. Trofimenko A7
  7. Navasardyan G8
  8. Jndoyan Z9
  9. Abgaryan K10
  10. Fogacci F9
  11. Galli M10
  12. Agati L11
  13. Kobalava Z12
  14. Shafie D13
  15. Marzilli M14
  16. Gogiashvili L15
  17. Sarrafzadegan N16
Show Affiliations
Authors Affiliations
  1. 1. Pathological Anatomy and Clinical Morphology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  2. 2. National Medical Research Centre of Cardiology after E. Chazov, Moscow, Russian Federation
  3. 3. Research Institute of Human Morphology FSBI «Petrovskiy NRCS, Moscow, Russian Federation
  4. 4. Pharmacology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Razi Drug Research Centre, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Siberian State Medical University, Tomsk, Russian Federation
  7. 7. Pathophysiology Department, Kuban State Medical University, Krasnodar, Russian Federation
  8. 8. Pathophysiology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
  9. 9. Atherosclerosis and Metabolic Disorders Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy
  10. 10. Maria Cecilia Hospital, GVM Care and Research, Catignola, Italy
  11. 11. Cardiology Department, Azienda Policlinico Umberto II, Sapienza University, Rome, Italy
  12. 12. Internal Disease and Clinical Pharmacology Department, Peoples Friendship University of Russia (RUDN), Moscow, Russian Federation
  13. 13. Isfahan Cardiovascular Research Institute, Isfahan, Iran
  14. 14. Cardiovascular Medicine Division, University of Pisa, Pisa, Italy
  15. 15. Head of Experimental and Clinical Pathology Department, Al. Natishvili Institute of Experimental Morphology, I. Javakhishvili Tbilisi State University, Tbilisi, Georgia
  16. 16. Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Current Problems in Cardiology Published:2023


Abstract

The infection caused by the Human Immunodeficiency Virus (HIV) has spread rapidly across the globe, assuming the characteristics of an epidemic in some regions. Thanks to the introduction of antiretroviral therapy into routine clinical practice, there was a considerable breakthrough in the treatment of HIV, that is now HIV is potentially well-controlled even in low-income countries. To date, HIV infection has moved from the group of life-threatening conditions to the group of chronic and well controlled ones and the quality of life and life expectancy of HIV+ people, with an undetectable viral load is closer to that of an HIV− people. However, unsolved issues still persist. For example: people living with HIV are more prone to the age-related diseases, especially atherosclerosis. For this reason, a better understanding of the mechanisms of HIV-associated destabilization of vascular homeostasis seems to be an urgent duty, that may lead to the development of new protocols, bringing the possibilities of pathogenetic therapies to a new level. The purpose of the article was to evaluate the pathological aspects of HIV-induced atherosclerosis. © 2023 Elsevier Inc.