Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Distinct Patterns of Hippocampal Subfield Volume Loss in Left and Right Mesial Temporal Lobe Epilepsy Publisher Pubmed



Moghaddam HS1 ; Aarabi MH1 ; Mehvarihabibabadi J2 ; Sharifpour R3, 4 ; Mohajer B5 ; Mohammadimobarakeh N3, 4 ; Hashemifesharaki SS6 ; Elisevich K7 ; Nazemzadeh MR3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Research Center for Molecular and Cellular Imaging, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  6. 6. Pars Advanced Medical Research Center, Pars Hospital, Tehran, Iran
  7. 7. Department of Clinical Neurosciences, Spectrum Health, College of Human Medicine, Michigan State University, Grand Rapids, 49503, MI, United States

Source: Neurological Sciences Published:2021


Abstract

Objective: To investigate the pattern and severity of hippocampal subfield volume loss in patients with left and right mesial temporal lobe epilepsy (mTLE) using quantitative MRI volumetric analysis. Methods: A total of 21 left and 14 right mTLE subjects, as well as 15 healthy controls, were enrolled in this cross-sectional study. A publically available magnetic resonance imaging (MRI) brain volumetry system (volBrain) was used for volumetric analysis of hippocampal subfields. The T1-weighted images were processed with a HIPS pipeline. Results: A distinct pattern of hippocampal subfield atrophy was found between left and right mTLE patients when compared with controls. Patients with left mTLE exhibited ipsilateral hippocampal atrophy and segmental volume depletion of the Cornu Ammonis (CA) 2/CA3, CA4/dentate gyrus (DG), and strata radiatum-lacunosum-moleculare (SR-SL-SM). Those with right mTLE exhibited similar ipsilateral hippocampal atrophy but with additional segmental CA1 volume depletion. More extensive bilateral subfield volume loss was apparent with right mTLE patients. Conclusion: We demonstrate that left and right mTLE patients show a dissimilar pattern of hippocampal subfield atrophy, suggesting the pathophysiology of epileptogenesis in left and right mTLE to be different. © 2020, Fondazione Societa Italiana di Neurologia.
Related Docs
View other Related Docs
1. Temporal and Extratemporal Atrophic Manifestation of Temporal Lobe Epilepsy Using Voxel-Based Morphometry and Corticometry: Clinical Application in Lateralization of Epileptogenic Zone, Neurological Sciences (2021)
2. Alteration of Intracranial Blood Perfusion in Temporal Lobe Epilepsy, an Arterial Spin Labeling Study, Heliyon (2023)
3. Comparison of Multimodal Findings on Epileptogenic Side in Temporal Lobe Epilepsy Using Self-Organizing Maps, Magnetic Resonance Materials in Physics, Biology and Medicine (2022)
4. White Matter and Subcortical Gray Matter Microstructural Integrity in Mesial Temporal Lobe Epilepsy: A Combined Diffusion Tensor and Kurtosis Imaging Study, Frontiers in Biomedical Technologies (2020)
5. A Novel Approach for Extracting Functional Brain Networks Involved in Mesial Temporal Lobe Epilepsy Based on Self Organizing Maps, Informatics in Medicine Unlocked (2022)
6. Cortical Thickness Analysis in Temporal Lobe Epilepsy Using Fully Bayesian Spectral Method in Magnetic Resonance Imaging, BMC Medical Imaging (2022)
7. Exploring Asl Perfusion Mri As a Substitutive Modality for 18F-Fdg Pet in Determining the Laterality of Mesial Temporal Lobe Epilepsy, Neurological Sciences (2024)
8. Dynamic Functional Connectivity in Temporal Lobe Epilepsy: A Graph Theoretical and Machine Learning Approach, Neurological Sciences (2021)
Experts (# of related papers)
View all Related Experts
Jafar Mehvari Habibabadi (14)
Vahid Shaygannejad (1)
Other Related Docs
9. Graph Theory Application With Functional Connectivity to Distinguish Left From Right Temporal Lobe Epilepsy, Epilepsy Research (2020)
10. Effect of Deep Gray Matter Atrophy on Information Processing Speed in Early Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2023)
11. Comparison of Blood Perfusion Parameters in the Ipsilateral and Contralateral Sides of the Brain in Known Cases of Mesial Temporal Lobe Epilepsy, Iranian Journal of Radiology (2021)
12. Correlative Study Between Magnetic Resonance Imaging (Mri) Findings and Interictal Spike Rate in Patients With Refractory Temporal Lobe Epilepsy, Journal of Isfahan Medical School (2017)
13. Evaluation of Cognitive Impairment in Refractory Temporal Lobe Epilepsy Patients With Respect to Structural Brain Lesions, Basic and Clinical Neuroscience (2023)
14. Correlation of Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging With Findings of Electroencephalography in Patients With Temporal Lobe Epilepsy, Journal of Medical Radiation Sciences (2024)
15. Effect of Long-Lasting Phenobarbital Administration on the Volume of Hippocampal Regions in Rat, Journal of Isfahan Medical School (2009)
16. 1H-Mrs Metabolite's Ratios Show Temporal Alternation in Temporal Lobe Seizure: Comparison Between Interictal and Postictal Phases, Epilepsy Research (2016)