Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Selective Serotonin Reuptake Inhibitors: New Hope in the Fight Against Covid-19 Publisher



Asadi Anar M1 ; Foroughi E2 ; Sohrabi E3 ; Peiravi S4 ; Tavakoli Y5 ; Kameli Khouzani M6 ; Behshood P7 ; Shamshiri M8 ; Faridzadeh A9, 10 ; Keylani K11 ; Langari SF12 ; Ansari A13 ; Khalaji A14 ; Garousi S15 Show All Authors
Authors
  1. Asadi Anar M1
  2. Foroughi E2
  3. Sohrabi E3
  4. Peiravi S4
  5. Tavakoli Y5
  6. Kameli Khouzani M6
  7. Behshood P7
  8. Shamshiri M8
  9. Faridzadeh A9, 10
  10. Keylani K11
  11. Langari SF12
  12. Ansari A13
  13. Khalaji A14
  14. Garousi S15
  15. Mottahedi M15
  16. Honari S15
  17. Deravi N1
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran
  4. 4. Department of Emergency Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Medicine, Mazandaran University of Medical Sciences, Mazandaran, Sari, Iran
  6. 6. Department of Biology, Science, and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Microbiology, Young Researchers and Elite Club, Islamic Azad University, Shahrekord, Iran
  8. 8. School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  9. 9. Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Department of Ophthalmology, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Shantou University Medical College, Guangdong, Shantou, China
  14. 14. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  15. 15. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Frontiers in Pharmacology Published:2022


Abstract

The emerging COVID-19 pandemic led to a dramatic increase in global mortality and morbidity rates. As in most infections, fatal complications of coronavirus affliction are triggered by an untrammeled host inflammatory response. Cytokine storms created by high levels of interleukin and other cytokines elucidate the pathology of severe COVID-19. In this respect, repurposing drugs that are already available and might exhibit anti-inflammatory effects have received significant attention. With the in vitro and clinical investigation of several studies on the effect of antidepressants on COVID-19 prognosis, previous data suggest that selective serotonin reuptake inhibitors (SSRIs) might be the new hope for the early treatment of severely afflicted patients. SSRIs’ low cost and availability make them potentially eligible for COVID-19 repurposing. This review summarizes current achievements and literature about the connection between SSRIs administration and COVID-19 prognosis. Copyright © 2022 Asadi Anar, Foroughi, Sohrabi, Peiravi, Tavakoli, Kameli Khouzani, Behshood, Shamshiri, Faridzadeh, Keylani, Langari, Ansari, Khalaji, Garousi, Mottahedi, Honari and Deravi.
Related Docs
View other Related Docs
1. Drug Repositioning Approach to Target Viral and Host Cells in Terms of Covid-19 Treatment: A Review of in Vivo Experiments and Clinical Studies, Journal of Experimental and Clinical Medicine (Turkey) (2022)
2. Covid-19 and the Potential of Janus Family Kinase (Jak) Pathway Inhibition: A Novel Treatment Strategy, Frontiers in Medicine (2022)
3. Acute Kidney Injury in Covid-19 Patients Receiving Remdesivir: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinics (2023)
4. Thrombotic Storm in Coronavirus Disease 2019: From Underlying Mechanisms to Its Management, Journal of Medical Microbiology (2022)
5. Epidemiology, Virology, Clinical Features, Diagnosis, and Treatment of Sars-Cov-2 Infection, Journal of Experimental and Clinical Medicine (Turkey) (2021)
6. Maprotiline Inhibits Cox2 and Inos Gene Expression in Lipopolysaccharide-Stimulated U937 Macrophages and Carrageenan-Induced Paw Edema in Rats, Central European Journal of Immunology (2019)
7. Potential Inhibitors of Sars-Cov-2: Recent Advances, Journal of Drug Targeting (2021)
8. Cytokines and Micrornas in Sars-Cov-2: What Do We Know?, Molecular Therapy Nucleic Acids (2022)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (8)
Ramin Sami (5)
Other Related Docs
9. Evaluation of the Effect of Antidepressant Drug, Fluvoxamine, on Cyclooxygenase-2 Protein Expression in Lipopolysaccharide-Stimulated Macrophages, Advanced Biomedical Research (2019)
10. Efficacy of Plasmapheresis in Neutropenic Patients Suffering From Cytokine Storm Because of Severe Covid-19 Infection, Blood Research (2023)
11. A Comprehensive Review of Therapeutic Options for Covid-19, Ethiopian Journal of Health Development (2022)
12. The Severity of Symptoms and Outcomes of Patients Admitted With Rheumatic Diseases and Covid-19; a Prospective Cohort Study in Iran, Immunopathologia Persa (2021)
13. Convalescent Plasma Therapy for Covid-19: Lessons From Sars-Cov, Mers-Cov, and H1n1 Infection, Acta Medica Indonesiana (2021)
14. In Vitro and in Vivo Modulation of Lps and Carrageenan-Induced Expression of Inflammatory Genes by Amitriptyline, Journal of Pharmacy and Pharmacognosy Research (2017)
15. Treatment of Covid-19 With Pentoxifylline: Could It Be a Potential Adjuvant Therapy?, Dermatologic Therapy (2020)
16. Current Status of Covid-19 Pandemic; Characteristics, Diagnosis, Prevention, and Treatment, Journal of Research in Medical Sciences (2020)
17. Infliximab and Intravenous Gammaglobulin in Hospitalized Severe Covid-19 Patients in Intensive Care Unit, Archives of Iranian Medicine (2021)
18. A Narrative Literature Review on Traditional Medicine Options for Treatment of Corona Virus Disease 2019 (Covid-19), Complementary Therapies in Clinical Practice (2020)
19. Pi3k/Akt/Mtor Pathway: A Potential Target for Anti-Sars-Cov-2 Therapy, Immunologic Research (2022)
20. Epidemiological Study of Covid-19 in Iran and the World: A Review Study, Infectious Disorders - Drug Targets (2022)
21. Cancer Patients’ Challenges During Covid-19 Pandemic: An Approach to Decision-Making in Management and Policy-Making, Archives of Clinical Infectious Diseases (2021)
22. Cancer Occurrence As the Upcoming Complications of Covid-19, Frontiers in Molecular Biosciences (2022)
23. A Study on the Effect of Aspirin on Clinical Symptoms, Laboratory Indices, and Outcomes in Patients With Covid-19, Journal of Nephropharmacology (2023)
24. Evaluation of the Effect of Montelukast Drug in Improving the Clinical Condition of Patients With Covid-19 in Referral Hospitals in Isfahan; a Randomized Clinical Trial, Journal of Nephropharmacology (2024)
25. An Experimental in Silico Study on Covid-19: Response of Neutrophil-Related Genes to Antibiotics, Health Science Reports (2022)
26. The Covid-19 Pandemic: A Systematic Review of the Current Evidence; [Пандемия Covid-19: Систематический Обзор Современных Данных], Russian Journal of Infection and Immunity (2020)
27. Sars-Cov-2 (Covid-19): New Discoveries and Current Challenges, Applied Sciences (Switzerland) (2020)
28. Prevention of Covid-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions, Advances in Experimental Medicine and Biology (2021)
29. Cardiovascular Complications of Sars-Cov-2 Vaccines: An Overview, Cardiology and Therapy (2022)
30. Covid-19 Management in the Emergency Ward, Journal of Research in Medical Sciences (2021)
31. Recent Findings of Coronavirus: The Pathogenesis and Treatment, Journal of Isfahan Medical School (2020)
32. Remdesivir Prescription in Pregnant Women Infected With Covid-19: A Report of Compassionate Use, Advanced Biomedical Research (2023)
33. Therapeutic Targets of Natural Products for the Management of Cardiovascular Symptoms of Coronavirus Disease 2019, Phytotherapy Research (2021)
34. Thalidomide for the Treatment of Covid-19 Pneumonia: A Randomized Controlled Clinical Trial, Advanced Biomedical Research (2023)
35. A Complementary Critical Appraisal on Systematic Reviews Regarding the Most Efficient Therapeutic Strategies for the Current Covid-19 (Sars-Cov-2) Pandemic, Journal of Medical Virology (2021)
36. The Role of Cytokine Profile and Lymphocyte Subsets in the Severity of Coronavirus Disease 2019 (Covid-19): A Systematic Review and Meta-Analysis, Life Sciences (2020)
37. A Mini-Review on Cardiovascular and Hematological Complications of Covid-19, Coronaviruses (2021)
38. The Kinetics of Inhibitory Immune Checkpoints During and Post-Covid-19: The Knowns and Unknowns, Clinical and Experimental Medicine (2023)
39. Effectiveness of Levamisole in the Treatment of Patients With Severe Covid-19: A Randomized Controlled Clinical Trial, Journal of Infection in Developing Countries (2024)
40. Unexpected Positive Effects of Rituximab and Corticosteroids on Covid-19 in a Patient Suffering From Granulomatosis With Polyangiitis, Advanced Biomedical Research (2021)
41. N-Acetylcysteine and Coronavirus Disease 2019: May It Work As a Beneficial Preventive and Adjuvant Therapy? a Comprehensive Review Study, Journal of Research in Medical Sciences (2020)
42. Immune Responses to Corona Family Viruses and Vaccine Strategies, Journal of Isfahan Medical School (2020)
43. Intravenous Methylprednisolone Pulse As a Treatment for Hospitalised Severe Covid-19 Patients: Results From a Randomised Controlled Clinical Trial, European Respiratory Journal (2020)
44. Covid-19 and the Risk of Relapse in Multiple Sclerosis Patients: A Fight With No Bystander Effect?, Multiple Sclerosis and Related Disorders (2021)
45. Prediabetes and Covid-19 Severity, an Underestimated Risk Factor: A Systematic Review and Meta-Analysis, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2021)
46. Covid-19 Pandemic: Insights Into Genetic Susceptibility to Sars-Cov-2 and Host Genes Implications on Virus Spread, Disease Severity and Outcomes, Human Antibodies (2022)
47. The Role of Serum Circulating Microbial Toxins in Severity and Cytokine Storm of Covid Positive Patients, Microbial Pathogenesis (2023)
48. Covid-19 Infection and Hospitalization Rate in Iranian Multiple Sclerosis Patients: What We Know by May 2021, Multiple Sclerosis and Related Disorders (2022)
49. Novel Drug Design for Treatment of Covid-19: A Systematic Review of Preclinical Studies, Canadian Journal of Infectious Diseases and Medical Microbiology (2022)
50. The Role of Immune Regulatory Molecules in Covid-19, Viral Immunology (2022)