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Therapeutic Potential of Berries in Age-Related Neurological Disorders Publisher



Norouzkhani N1 ; Afshari S2 ; Sadatmadani SF3 ; Mollaqasem MM4 ; Mosadeghi S2 ; Ghadri H4 ; Fazlizade S5 ; Alizadeh K5 ; Akbari Javar P6 ; Amiri H7 ; Foroughi E3 ; Ansari A8 ; Mousazadeh K9 ; Davany BA10 Show All Authors
Authors
  1. Norouzkhani N1
  2. Afshari S2
  3. Sadatmadani SF3
  4. Mollaqasem MM4
  5. Mosadeghi S2
  6. Ghadri H4
  7. Fazlizade S5
  8. Alizadeh K5
  9. Akbari Javar P6
  10. Amiri H7
  11. Foroughi E3
  12. Ansari A8
  13. Mousazadeh K9
  14. Davany BA10
  15. Akhtari Kohnehshahri A11
  16. Alizadeh A12
  17. Dadkhah PA13
  18. Poudineh M14
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  6. 6. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
  7. 7. Student Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran
  8. 8. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  9. 9. School of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  10. 10. Student Research Committee, School of Medicine, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  11. 11. Student Research Committee, Faculty of Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
  12. 12. Student Research Committee, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran
  13. 13. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  14. 14. Student Research Committee, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Frontiers in Pharmacology Published:2024


Abstract

Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer’s, Parkinson’s, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines. The ancient medical system used many botanical drugs and medicinal plants to treat a wide range of diseases, including age-related neurological problems. According to current clinical investigations, berries improve motor and cognitive functions and protect against age-related neurodegenerative diseases. Additionally, berries may influence signaling pathways critical to neurotransmission, cell survival, inflammation regulation, and neuroplasticity. The abundance of phytochemicals in berries is believed to contribute to these potentially neuroprotective effects. This review aimed to explore the potential benefits of berries as a source of natural neuroprotective agents for age-related neurological disorders. Copyright © 2024 Norouzkhani, Afshari, Sadatmadani, Mollaqasem, Mosadeghi, Ghadri, Fazlizade, Alizadeh, Akbari Javar, Amiri, Foroughi, Ansari, Mousazadeh, Davany, Akhtari kohnehshahri, Alizadeh, Dadkhah and Poudineh.
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