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Effects of Decellularized Extracellular Matrix on Polyhydroxybutyrate Electrospun Scaffolds for Cartilage Tissue Engineering Publisher



Asgharivostakolaei M1 ; Bahramian H1 ; Karbasi S2 ; Setayeshmehr M3
Authors
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Authors Affiliations
  1. 1. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Polymer-Plastics Technology and Materials Published:2023


Abstract

The current study was carried out to evaluate the effects of cartilage-decellularized extracellular matrix (ECM) on Poly (3-hydroxybutyrate) (PHB) electrospun scaffold for cartilage tissue engineering. In this study, PHB scaffolds with three different percentages of ECM (1%, 2%, and 3%) were fabricated. Mechanical, chemical, and physical properties of scaffolds along with their interactions with cells were assessed. Results showed that by adding of ECM to the scaffolds, the Physiomechanical properties of combined scaffolds were modified, compared to the pure PHB scaffold. In the other hand, the biological behavior was increased by increasing the ECM ratio to the PHB. © 2022 Taylor & Francis.
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