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Approach to the Management of Autoimmunity in Primary Immunodeficiency Publisher Pubmed



Azizi G1, 2 ; Ziaee V3, 4 ; Tavakol M5 ; Alinia T2 ; Yazdai R2, 6 ; Mohammadi H7 ; Abolhassani H2, 8 ; Aghamohammadi A2
Authors
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Authors Affiliations
  1. 1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Allergy and Clinical Immunology, Shahid Bahonar Hospital, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

Source: Scandinavian Journal of Immunology Published:2017


Abstract

Primary immunodeficiency diseases (PIDs) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non-infectious complications, particularly autoimmunity. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and leads to difficulty in the management of autoimmune complications in PID patients. Therefore, management of autoimmunity in patients with PID requires special considerations because dysregulations and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment. © 2016 The Foundation for the Scandinavian Journal of Immunology
2. Autoimmunity in Primary Antibody Deficiencies, International Archives of Allergy and Immunology (2017)
3. Autoimmunity in Primary T-Cell Immunodeficiencies, Expert Review of Clinical Immunology (2016)
4. The Use of Immunoglobulin Therapy in Primary Immunodeficiency Diseases, Endocrine, Metabolic and Immune Disorders - Drug Targets (2016)
5. Noninfectious Complications in B-Lymphopenic Common Variable Immunodeficiency, Journal of Investigational Allergology and Clinical Immunology (2024)
7. Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders, Journal of Investigational Allergology and Clinical Immunology (2017)
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