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Impact of Selenium Nanoparticle-Enriched Lactobacilli Feeding Against Escherichia Coli O157:H7 Infection of Balb/C Mice Publisher Pubmed



Esfandiari Z1 ; Vakili B2 ; Ahangarzadeh S2 ; Esfahani SN3 ; Shoaei P4
Authors
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Authors Affiliations
  1. 1. Department of Food Science and Technology, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Probiotics and Antimicrobial Proteins Published:2024


Abstract

The effectiveness of selenium nanoparticle (SeNP)-enriched Lactiplantibacillus plantarum and Lactobacillus acidophilus was studied against Shiga toxin-producing Escherichia coli O157:H7 infection on the intestinal fragments and kidney tissue of BALB/c mice. Gut microbiota-targeted bacteria and E. coli O157:H7 counts were obtained by qPCR and PCR. Histology of ileum, colon, and kidney tissues and Stx secretions were analyzed until one-week post-infection. Mice fed with SeNP Lpb. plantarum in the preinfection feeding groups have lower E. coli O157:H7 counts and lower intestinal damage than those in the infected group. The lowest mean fecal probiotic counts were in the L. acidophilus group (7.61 log 10). In pretreatment groups of SeNP L. acidophilus and L. acidophilus, the mean counts of bacteria decreased to 104 CFU/g by day 7. The lowest Stx copy number was demonstrated in SeNP Lpb. plantarum feeding groups’ day 7 (P < 0.05). Feeding groups with SeNP Lpb. plantarum had significantly higher members of Lactobacilli in their fecal microbiota than the control group on day 7. It was clarified that Se-enriched Lpb. plantarum and L. acidophilus can be useful as a method of preventing STEC infections. The viability of STEC infection exposure to selenium-enriched Lactobacillus spp. was decreased more than for non-Se-enriched Lactobacillus spp. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.
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