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Impact of Sars-Cov-2 Pandemic on Patients With Primary Immunodeficiency Publisher Pubmed



Delavari S1 ; Abolhassani H1, 2 ; Abolnezhadian F3 ; Babaha F1, 4 ; Iranparast S5 ; Ahanchian H6 ; Moazzen N6 ; Nabavi M7 ; Arshi S7 ; Fallahpour M7 ; Bemanian MH7 ; Shokri S7 ; Momen T8 ; Sadeghishabestari M9 Show All Authors
Authors
  1. Delavari S1
  2. Abolhassani H1, 2
  3. Abolnezhadian F3
  4. Babaha F1, 4
  5. Iranparast S5
  6. Ahanchian H6
  7. Moazzen N6
  8. Nabavi M7
  9. Arshi S7
  10. Fallahpour M7
  11. Bemanian MH7
  12. Shokri S7
  13. Momen T8
  14. Sadeghishabestari M9
  15. Molatefi R10
  16. Shirkani A11
  17. Vosughimotlagh A12
  18. Safarirad M12
  19. Sharifzadeh M13
  20. Pashangzadeh S1
  21. Salami F1
  22. Shirmast P1
  23. Rezaei A1
  24. Moeini Shad T1
  25. Mohraz M14
  26. Rezaei N1
  27. Hammarstrom L2
  28. Yazdani R1
  29. Aghamohamamdi A1
Show Affiliations
Authors Affiliations
  1. 1. Research Center for Primary Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
  3. 3. Department of Pediatrics, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  5. 5. Department of immunology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Immunology research center of Tabriz, TB and lung research center of Tabriz, children hospital, Tabriz University of Medical Science, Tabriz, Iran
  10. 10. Department of Pediatrics, Bo-Ali Children’s Hospital of Ardabil University of Medical Sciences, Ardabil, Iran
  11. 11. Allergy and Clinical Immunology Department, Bushehr University of Medical Sciences, School of Medicine, Bushehr, Iran
  12. 12. Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran
  13. 13. Division of Pediatric Critical Care, Children Medical Center, Tehran University of Medical Science, Tehran, Iran
  14. 14. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical Immunology Published:2021


Abstract

Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents. © 2020, The Author(s).
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