Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparing the Efficacy of Prophylactic Intravenous Dexamethasone and Pethidine on Postoperative Shivering in Elective Cesarean Section Under Spinal Anaesthesia



Jabalameli M1 ; Radmanesh A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Postoperative shivering is an important complication following spinal anaesthesia. It is interferes with monitoring devices distressing to the patient and increases oxygen consumption. The aim of this study was to compare the effectiveness of pethidine and dexamethasone in the prevention of postoperative shivering after spinal anesthesia for caesarean section. Methods: In this prospective, randomized, double-blind study, 99 obstetric patients with ASA I–II (American Society of Anesthesiologists) undergoing elective caesarean section under spinal anaesthesia were randomly allocated to one of three equal groups: Group D received 0.15 mg/kg dexamethasone, Group P received 0.5 mg/kg pethidine and Group C (control) received normal saline. The drugs were given intravenously immediately after delivery of the infant with recording of axillary and core temperature and vital signs in several time intraoperative and every 10 minutes in recovery room. The incidence and intensity of shivering, number of patients received pethidine, sensory level, pain (in visual analogue scale), and side effects (hypotension, hypertension, tachycardia, bradycardia, sedation, nausea and vomiting) were also recorded. Findings: Incidence and intensity of shivering were reduced in groups P and D compared to group C (P < 0.05). The means of shivering score were 0.03, 0.15 and 0.27 in groups P, D and C, respectively. Receiving pethidine to control shivering after the surgery was significantly lower in groups P and D compared to group C (P < 0.05). There were no significant differences in vital signs, axillary and core temperature, sensory level and side effects among all groups. Conclusion: The prophylactic use of 0.15 mg/kg dexamethasone is effective for shivering prophylaxis in women undergoing cesarean section under spinal anaesthesia. © 2014, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. A Comparative Study on the Prophylactic Effects of Ketamine, Dexamethasone, and Pethidine in Preventing Postoperative Shivering, Journal of Research in Medical Sciences (2012)
2. Tramadol Versus Meperidine in the Treatment of Shivering During Spinal Anesthesia in Cesarean Section, Journal of Research in Medical Sciences (2006)
3. Comparison of the Effect of Dexamethasone, Midazolam, and Ondansetron Injection Alone, or in Combination, and Placebo on the Severity of Shivering During and After Spinal Anesthesia in Orthopedic Operations of the Lower Limb, Journal of Isfahan Medical School (2019)
4. Comparison of Prophylactic Use of Midazolam, Ketamine, and Ketamine Plus Midazolam for Prevention of Shivering During Regional Anaesthesia: A Randomized Double-Blind Placebo Controlled Trial, British Journal of Anaesthesia (2008)
5. The Intravenous Injection of Pethidine and Dexmedetomidine in the Prevention of Cesarean Postoperative Shivering Under Spinal Anesthesia: A Double-Blind Clinical Trial, Iranian Journal of Obstetrics, Gynecology and Infertility (2022)
6. Prevention of Shivering During Regional Anesthesia in Cesarean Section: Comparison of the Two Different Doses of Ketamine and Placebo, Journal of Isfahan Medical School (2016)
7. Evaluating the Prophylactic Effect of Magnesium Sulfate and Combination of Midazolam and Ketamine for Prevention of Shivering During Regional Anaesthesia, Journal of Isfahan Medical School (2016)
8. The Effect of Adding Sufentanyl or Pethidine to Intrathecal Marcaine for Prevention of Post-Operative Shivering in Patients Undergoing Herniated Disk Surgery, Journal of Isfahan Medical School (2016)
Experts (# of related papers)
View all Related Experts
Azim Honarmand (18)
Mohammad Reza Safavi (17)
Other Related Docs
9. Comparing Three Methods of Dexamethasone, Pethidine and Hyoscine in Prophylaxis of Postoperative Shivering After General Anesthesia, Journal of Isfahan Medical School (2015)
10. A Comparative Study on the Effect of Intravenous Dexamethasone, Ondansetron, and Ketamine in Preventing Postoperative Shivering in Cesarean Section Under General Anesthesia, Journal of Isfahan Medical School (2017)
11. Comparing Alfentanil, Sufentanil, Ketamine and Pethidine for Prevention of Postanesthetic Shivering: A Randomized Placebo-Controlled Clinical Trial, Journal of Isfahan Medical School (2015)
12. A Comparison on the Preventive Effect of 100 Mg and 200 Mg Oral Celecoxib on Shivering During and After Orthopedic Lower Extremity Surgery Under the Spinal Anesthesia; a Randomized Controlled Clinical Trial Study, Journal of Isfahan Medical School (2020)
13. Preventive Effect of Different Doses of Tramadol on Postoperative Shivering During and After Lower Limb Orthopedic Surgery Under Spinal Anesthesia As Compared to Control Group, Journal of Isfahan Medical School (2018)
14. Comparative Study of the Prophylactic Effects of Intravenous Injection of Dexmedetomidine, Ondansetron, and Pethidine on Postoperative Shivering of Abdominal Surgery Under General Anesthesia: A Randomized Clinical Trial, Advanced Biomedical Research (2021)
15. Comparison Study of Preemptive Effect of Intratechal Fentanyl With Intravenous Ondansetron, Dexamethasone, and Dexamethasone Plus Ondansetron on Shivering During Surgeries Under Spinal Anesthesia With Bupivacaine, Journal of Isfahan Medical School (2017)
16. The Effect of Intravenous Hydrocortisone (1 or 2 Mg/Kg) on Postoperative Shivering in Cesarean Section With Spinal Anesthesia, Journal of Isfahan Medical School (2017)
17. The Evaluation of Effects Two Different Doses of Hydrocortisone on the Intensity of Perioperative Shivering in Elective Surgery Under Spinal Anesthesia: A Double-Blind Randomized Controlled Trial Study, Journal of Research in Medical Sciences (2016)
18. Preemptive Effect of Pethidine, Ketamine and Ondansetron on Post-Operative Shivering in Patients Undergoing Abdominal Surgery With General Anesthesia, Journal of Isfahan Medical School (2016)
19. Efficacy of Granisetron in Preventing Postanesthetic Shivering, Acta Anaesthesiologica Taiwanica (2008)
20. Minimum Effective Dose of Tramadol in the Treatment of Postanesthetic Shivering, Journal of Research in Medical Sciences (2008)
21. Comparing the Effect of Paracetamol, Dexamethasone, and Paracetamol Plus Dexamethasone on Prevention of Postoperative Headache in Pregnant Women Undergoing Cesarean Section With Spinal Anesthesia, Journal of Isfahan Medical School (2018)
22. Comparing the Hemodynamic Effects of Nebulized Dexmedetomidine and Nebulized Lidocaine in Children Undergoing Fiberoptic Bronchoscopy, Journal of Advances in Medical and Biomedical Research (2019)
23. Postoperative Residual Block in Postanesthesia Care Unit More Than Two Hours After the Administration of a Single Intubating Dose of Atracurium, Journal of Research in Medical Sciences (2011)
24. The Efficacy of Prophylactic Intravenous Aminophylline, Paracetamol or Aminophylline and Paracetamol in Prevention of Post Spinal Headache in Lower Extremity Surgeries Compared to the Control Group, Tehran University Medical Journal (2019)
25. Comparing the Effects of Low Doses of Propofol, Ketamine and Combination of Propofol-Ketamine in Prevention of Post-Extubation Coughing and Laryngospasm, Journal of Isfahan Medical School (2014)
26. The Effect of Early Ambulation on the Incidence of Neurological Complication After Spinal Anesthesia With Lidocaine, Journal of Research in Medical Sciences (2015)
27. Comparing the Preemptive Effect of 4 and 8 Mg Intracuff Dexamethasone on Postoperative Sore Throat and Cough, Journal of Isfahan Medical School (2019)
28. A Comparative Study of the Effect of Adding Dexmedetomidine, Dexamethasone and Sodium Bicarbonate to Ropivacaine in Ultrasound Guided Supraclavicular Block on the Quality of the Block in Orthopedic Surgery, Archives of Anesthesiology and Critical Care (2024)
29. Baricity of Bupivacaine on Maternal Hemodynamics After Spinal Anesthesia for Cesarean Section: A Randomized Controlled Trial, Iranian Journal of Medical Sciences (2017)
30. Comparison of Dexmedetomidine Versus Midazolam on Hemodynamic Parameters, Bleeding, Satisfaction of Surgeons and Patients Who Underwent Laminectomy Surgery by Spinal Anesthesia, Tehran University Medical Journal (2021)
31. Comparing the Effects of Ketamine Alone and in Combination With Metoclopramide on Postoperative Pain, Journal of Isfahan Medical School (2013)
32. Frequency of Pain Intensity and Factors Affecting It After Cesarean Section Using Spinal Anesthesia, Archives of Anesthesiology and Critical Care (2025)
33. The Effects of Intravenous Fluids Temperature on Perioperative Hemodynamic Situation, Post-Operative Shivering, and Recovery in Orthopaedic Surgery., Canadian operating room nursing journal (2007)
34. Supplementing Epidural Lidocaine With Midazolam: Effect on Sensorymotor Block Level, Acta Anaesthesiologica Taiwanica (2004)
35. Comparison Between the Effect of Bupivacaine-Pethidine and Bupivacaine-Ketamine As Preemptive in Bilateral Infraorbital Nerve Block on Postoperative Pain Relief in Infants Undergoing Clef Lip Repair, a Controlled Study, Journal of Isfahan Medical School (2017)
36. Comparative Evaluation of the Effects of Three Doses of Intravenous Magnesium Sulfate on Postoperative Shivering After Abdominal Surgeries Under General Anesthesia, Journal of Isfahan Medical School (2016)
37. Bispectral Index Values During Spinal Anesthesia Using Hyperbaric Bupivacaine With Intrathecal or Intravenous Fentanyl for Cesarean Section, Journal of Research in Medical Sciences (2012)
38. Prophylactic Effects of Intravenous Dexamethasone and Lidocaine on Attenuating Hemodynamic-Respiratory and Pain Complications in Children Undergoing Cleft Palate Repair Surgery With General Anesthesia, Journal of Pain and Palliative Care Pharmacotherapy (2020)
39. A Comparative Study of the Effect of Low-Dose Epinephrine and Ketamine on Rapid-Sequence Endotracheal Intubation by the Priming Dose Method of Cisatracurium in Patients Under General Anesthesia, Advanced Biomedical Research (2023)
40. Midazolam Versus Ketamine in the Management of Emergence Agitation in Children Undergoing Lower Abdominal and Limb Surgeries, Tehran University Medical Journal (2012)
41. A Comparison of the Effects of Fentanyl and Remifentanil on Nausea, Vomiting, and Pain After Cesarean Section, Iranian Journal of Medical Sciences (2011)
42. Comparison of the Effects of Intravenous or Subcutaneous Administration of Metoclopramide on Pain and Nausea After Lower Abdominal Surgery, Journal of Isfahan Medical School (2021)
43. Comparison of the Effect of Spinal, Epidural, and Combined of Neuroaxial Anesthesia on Maternal and Fetal Outcomes of Normal Vaginal Delivery: A Clinical Trial Study, Journal of Isfahan Medical School (2019)
44. Assessing Intravenous Ketamine and Intravenous Dexamethasone Separately and in Combination for Early Oral Intake, Vomiting and Postoperative Pain Relief in Children Following Tonsillectomy., Medicinski arhiv (2012)
45. Analgesic Efficacy of Dexamethasone and Dexmedetomidine As an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study, Archives of Anesthesiology and Critical Care (2024)
46. Premedication With Oral Dextromethorphan Reduces Intra-Operative Morphine Requirement, Journal of Research in Medical Sciences (2005)
47. Rectal Diclofenac Versus Rectal Paracetamol: Comparison of Antipyretic Effectiveness in Children, Iranian Red Crescent Medical Journal (2016)
48. Analgesic Effects of Intra-Articular Fentanyl, Pethidine and Dexamethasone Arter Knee Arthroscopic Surgery, Journal of Research in Medical Sciences (2006)
49. Comparing the Prophylactic Effect of Two Different Methods of Administration of Dexamethasone (Intracuff and Intravenous) on Postoperative Sore Throat and Cough, Journal of Isfahan Medical School (2019)
50. Comparison of Adding Neostigmine and Fentanyl to Bupivacaine in Caudal Analgesia Caudal in Pediatric Inguinal Herniorrhaphy, Journal of Cellular and Molecular Anesthesia (2017)