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Comparative Trial of Intravenous Dexmedetomidine Versus Midazolam Premedication on Quality of Sedation in Upper Gastrointestinal Endoscopy in Children



Shafa A1 ; Hirmanpour A1 ; Aghadavoudi O1 ; Ghasvarian A2
Authors
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Authors Affiliations
  1. 1. Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2017

Abstract

Background: Upper gastrointestinal endoscopy is one of the most common outpatient diagnostic and therapeutic interventions in children. Present study aimed to compare the sedative effect of intravenous dexmedetomidine premedication versus midazolam in children undergoing upper gastrointestinal endoscopy. Methods: This was a double-blind randomized trial in which 72 patients were allocated in two groups of 36 undergoing premedication with intravenous (IV) midazolam and dexmedetomidine, respectively. Sedation scale, mean arterial pressure, heart rate, recovery time, and respiratory complications were recorded and compared. Findings: Sedation score was significantly higher with midazolam at 15 minutes following injection (P = 0.005), on admission to recovery (P < 0.001), and 30 minutes after admission to recovery (P = 0.001). Recovery time was significantly longer in midazolam premedication (P < 0.001). Respiratory complications were significantly more frequent with midazolam (P = 0.030). Conclusion: Although dexmedetomidine premedication was associated with lower mean arterial pressure and heart rate, intra-operative and recovery sedation scores were significantly higher with midazolam premedication. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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