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Expression of Blood Cells Associated Cd Markers and Cardiovascular Diseases: Clinical Applications in Prognosis Publisher Pubmed



Haybar H1 ; Maleki Behzad M2 ; Shahrabi S3 ; Ansari N4 ; Saki N2
Authors
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Authors Affiliations
  1. 1. Atherosclerosis Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Isfahan Bone Metabolic Disorders Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Lab Medicine Published:2020


Abstract

Background: Cardiovascular diseases (CVDs) are a major cause of mortality worldwide. The results of various studies have shown that abnormality in the frequency and function of blood cells can be involved in CVD complications. In this review, we have focused on abnormalities in the expression of the CD (cluster of differentiation) markers of blood cells to assess the association of these abnormalities with CVD prognosis. Methods: We identified the relevant literature through a PubMed search (1990-2018) of English-language articles using the terms Cardiovascular diseases, CD markers, leukocytes, platelets, and endothelial cells. Results: There is a variety of mechanisms for the effect of CD-marker expressions on CVDs prognosis, ranging from proinflammatory processes to dysfunctional effects in blood cells. Conclusion: Considering the possible effects of CD-marker expression on CVDs prognosis, particularly prognosis of acute myocardial infarction and atherosclerosis, long-term studies in large cohorts are required to identify the prognostic value of CD markers and to target them with appropriate therapeutic agents. © 2019 American Society for Clinical Pathology. All rights reserved.
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