Human Lfa-1 Governs T Cell Immune Surveillance of the Skin

Human Lfa-1 Governs T Cell Immune Surveillance of the Skin Publisher Pubmed

Yatim A ; Youssefian L ; Idani A ; Mourelatos H ; Olyaei NA ; Habibi L ; Peel JN ; Gaballa M ; Kim C ; Lee D ; Floch CL ; Chan YH ; Martinfernandez M ; Pelletier L Show All Authors

Yatim A
Youssefian L
Idani A
Mourelatos H
Olyaei NA
Habibi L
Peel JN
Gaballa M
Kim C
Lee D
Floch CL
Chan YH
Martinfernandez M
Pelletier L
Nakajima K
Fayand A
Momenilandi M
Seeleuthner Y
Chaldebas M
Saeidian AH
Mahmoudi H
Nikbakht N
Deswarte C
Kerrouche N
Sahel H
Parvaneh N
Tamizifar B
Sherkat R
Chanal J
Firooz A
Alizadeh Z
Lorenzodiaz L
Mariaggi AA
Ogishi M
Diep A
Hammadi B
Kerrouche N
Rinchai D
Sedighzadeh S
Mehrjooy S
Akrami SM
Lenormand C
Radosavljevic M
Rosain J
Zhang SY
Boisson B
Zhang P
Boissondupuis S
Krueger JG
Pretet JL
Waterboer T
Pourpak Z
Fazlollahi MR
Abel L
Bogunovic D
Shahrooei M
Cobat A
Carapito R
Molitor A
Vahidnezhad H
Beziat V
Bahram S
Jouanguy E
Casanova JL

Source: Science Immunology Published:2026

Abstract

The human integrin lymphocyte function–associated antigen 1 (LFA-1; αLβ2) is broadly expressed on leukocytes and involved in various intercellular adhesions. We report complete LFA-1 deficiency because of inherited αL (CD11a) deficiency in otherwise healthy adults of various ancestries with skin lesions due to commensal papillomaviruses. The patients had no history of invasive infections characteristic of children with inherited deficiency of β2 (CD18), which forms heterodimers with αL, αM (CD11b), αX (CD11c), or αD (CD11d). The development and function of leukocyte subsets are largely preserved in the absence of LFA-1. However, the transendothelial migration of skin-tropic cutaneous lymphocyte antigen (CLA)+ memory T cells is severely impaired, resulting in their selective sequestration in the blood. Conversely, alternative integrins mediate the extravasation of other leukocytes, including other T cell subsets, to other tissues. Human LFA-1 is required for steady-state T cell homing to the skin and control of papillomaviruses but is otherwise largely redundant. Integrin-mediated T cell compartmentalization is thus essential for organ-selective immune surveillance. © 2026 The Authors, some rights reserved;.

Style	Citing Format
MLA	Yatim A, et al.. "Human Lfa-1 Governs T Cell Immune Surveillance of the Skin." Science Immunology, vol. 11, no. 116, 2026, pp. -.
APA	Yatim A, Youssefian L, Idani A, Mourelatos H, Olyaei NA, Habibi L, Peel JN, Gaballa M, Kim C, Lee D, Floch CL, Chan YH, Martinfernandez M, Pelletier L, Nakajima K, Fayand A, Momenilandi M, Seeleuthner Y, Chaldebas M, ... Casanova JL (2026). Human Lfa-1 Governs T Cell Immune Surveillance of the Skin. Science Immunology, 11(116), -.
Chicago	Yatim A, Youssefian L, Idani A, Mourelatos H, Olyaei NA, Habibi L, Peel JN, et al.. "Human Lfa-1 Governs T Cell Immune Surveillance of the Skin." Science Immunology 11, no. 116 (2026): -.
Harvard	Yatim A et al. (2026) 'Human Lfa-1 Governs T Cell Immune Surveillance of the Skin', Science Immunology, 11(116), pp. -.
Vancouver	Yatim A, Youssefian L, Idani A, Mourelatos H, Olyaei NA, Habibi L, et al.. Human Lfa-1 Governs T Cell Immune Surveillance of the Skin. Science Immunology. 2026;11(116):-.
BibTex	@article{ author = {Yatim A and Youssefian L and Idani A and Mourelatos H and Olyaei NA and Habibi L and Peel JN and Gaballa M and Kim C and Lee D and Floch CL and Chan YH and Martinfernandez M and Pelletier L and Nakajima K and Fayand A and Momenilandi M and Seeleuthner Y and Chaldebas M and Saeidian AH and Mahmoudi H and Nikbakht N and Deswarte C and Kerrouche N and Sahel H and Parvaneh N and Tamizifar B and Sherkat R and Chanal J and Firooz A and Alizadeh Z and Lorenzodiaz L and Mariaggi AA and Ogishi M and Diep A and Hammadi B and Kerrouche N and Rinchai D and Sedighzadeh S and Mehrjooy S and Akrami SM and Lenormand C and Radosavljevic M and Rosain J and Zhang SY and Boisson B and Zhang P and Boissondupuis S and Krueger JG and Pretet JL and Waterboer T and Pourpak Z and Fazlollahi MR and Abel L and Bogunovic D and Shahrooei M and Cobat A and Carapito R and Molitor A and Vahidnezhad H and Beziat V and Bahram S and Jouanguy E and Casanova JL}, title = {Human Lfa-1 Governs T Cell Immune Surveillance of the Skin}, journal = {Science Immunology}, volume = {11}, number = {116}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Yatim A AU - Youssefian L AU - Idani A AU - Mourelatos H AU - Olyaei NA AU - Habibi L AU - Peel JN AU - Gaballa M AU - Kim C AU - Lee D AU - Floch CL AU - Chan YH AU - Martinfernandez M AU - Pelletier L AU - Nakajima K AU - Fayand A AU - Momenilandi M AU - Seeleuthner Y AU - Chaldebas M AU - Saeidian AH AU - Mahmoudi H AU - Nikbakht N AU - Deswarte C AU - Kerrouche N AU - Sahel H AU - Parvaneh N AU - Tamizifar B AU - Sherkat R AU - Chanal J AU - Firooz A AU - Alizadeh Z AU - Lorenzodiaz L AU - Mariaggi AA AU - Ogishi M AU - Diep A AU - Hammadi B AU - Kerrouche N AU - Rinchai D AU - Sedighzadeh S AU - Mehrjooy S AU - Akrami SM AU - Lenormand C AU - Radosavljevic M AU - Rosain J AU - Zhang SY AU - Boisson B AU - Zhang P AU - Boissondupuis S AU - Krueger JG AU - Pretet JL AU - Waterboer T AU - Pourpak Z AU - Fazlollahi MR AU - Abel L AU - Bogunovic D AU - Shahrooei M AU - Cobat A AU - Carapito R AU - Molitor A AU - Vahidnezhad H AU - Beziat V AU - Bahram S AU - Jouanguy E AU - Casanova JL TI - Human Lfa-1 Governs T Cell Immune Surveillance of the Skin JO - Science Immunology VL - 11 IS - 116 SP - EP - PY - 2026 ER -

Style

Citing Format

MLA

Yatim A, et al.. "Human Lfa-1 Governs T Cell Immune Surveillance of the Skin." Science Immunology, vol. 11, no. 116, 2026, pp. -.

APA

Yatim A, Youssefian L, Idani A, Mourelatos H, Olyaei NA, Habibi L, Peel JN, Gaballa M, Kim C, Lee D, Floch CL, Chan YH, Martinfernandez M, Pelletier L, Nakajima K, Fayand A, Momenilandi M, Seeleuthner Y, Chaldebas M, ... Casanova JL (2026). Human Lfa-1 Governs T Cell Immune Surveillance of the Skin. Science Immunology, 11(116), -.

Chicago

Yatim A, Youssefian L, Idani A, Mourelatos H, Olyaei NA, Habibi L, Peel JN, et al.. "Human Lfa-1 Governs T Cell Immune Surveillance of the Skin." Science Immunology 11, no. 116 (2026): -.

Harvard

Yatim A et al. (2026) 'Human Lfa-1 Governs T Cell Immune Surveillance of the Skin', Science Immunology, 11(116), pp. -.

Vancouver

Yatim A, Youssefian L, Idani A, Mourelatos H, Olyaei NA, Habibi L, et al.. Human Lfa-1 Governs T Cell Immune Surveillance of the Skin. Science Immunology. 2026;11(116):-.

BibTex

@article{ author = {Yatim A and Youssefian L and Idani A and Mourelatos H and Olyaei NA and Habibi L and Peel JN and Gaballa M and Kim C and Lee D and Floch CL and Chan YH and Martinfernandez M and Pelletier L and Nakajima K and Fayand A and Momenilandi M and Seeleuthner Y and Chaldebas M and Saeidian AH and Mahmoudi H and Nikbakht N and Deswarte C and Kerrouche N and Sahel H and Parvaneh N and Tamizifar B and Sherkat R and Chanal J and Firooz A and Alizadeh Z and Lorenzodiaz L and Mariaggi AA and Ogishi M and Diep A and Hammadi B and Kerrouche N and Rinchai D and Sedighzadeh S and Mehrjooy S and Akrami SM and Lenormand C and Radosavljevic M and Rosain J and Zhang SY and Boisson B and Zhang P and Boissondupuis S and Krueger JG and Pretet JL and Waterboer T and Pourpak Z and Fazlollahi MR and Abel L and Bogunovic D and Shahrooei M and Cobat A and Carapito R and Molitor A and Vahidnezhad H and Beziat V and Bahram S and Jouanguy E and Casanova JL}, title = {Human Lfa-1 Governs T Cell Immune Surveillance of the Skin}, journal = {Science Immunology}, volume = {11}, number = {116}, pages = {-}, year = {2026} }

RIS

TY - JOUR
AU - Yatim A
AU - Youssefian L
AU - Idani A
AU - Mourelatos H
AU - Olyaei NA
AU - Habibi L
AU - Peel JN
AU - Gaballa M
AU - Kim C
AU - Lee D
AU - Floch CL
AU - Chan YH
AU - Martinfernandez M
AU - Pelletier L
AU - Nakajima K
AU - Fayand A
AU - Momenilandi M
AU - Seeleuthner Y
AU - Chaldebas M
AU - Saeidian AH
AU - Mahmoudi H
AU - Nikbakht N
AU - Deswarte C
AU - Kerrouche N
AU - Sahel H
AU - Parvaneh N
AU - Tamizifar B
AU - Sherkat R
AU - Chanal J
AU - Firooz A
AU - Alizadeh Z
AU - Lorenzodiaz L
AU - Mariaggi AA
AU - Ogishi M
AU - Diep A
AU - Hammadi B
AU - Kerrouche N
AU - Rinchai D
AU - Sedighzadeh S
AU - Mehrjooy S
AU - Akrami SM
AU - Lenormand C
AU - Radosavljevic M
AU - Rosain J
AU - Zhang SY
AU - Boisson B
AU - Zhang P
AU - Boissondupuis S
AU - Krueger JG
AU - Pretet JL
AU - Waterboer T
AU - Pourpak Z
AU - Fazlollahi MR
AU - Abel L
AU - Bogunovic D
AU - Shahrooei M
AU - Cobat A
AU - Carapito R
AU - Molitor A
AU - Vahidnezhad H
AU - Beziat V
AU - Bahram S
AU - Jouanguy E
AU - Casanova JL
TI - Human Lfa-1 Governs T Cell Immune Surveillance of the Skin
JO - Science Immunology
VL - 11
IS - 116
SP -
EP -
PY - 2026
ER -

Science Communicator Platform

Authors

Abstract